Failure of atovaquone-proguanil malaria chemoprophylaxis in a traveler to Ghana

被引：11
|
作者：
Boggild, Andrea K. [1 ,2 ,3 ]
Lau, Rachel [3 ]
Reynaud, Denis [4 ]
Kain, Kevin C. [1 ,2 ,5 ]
Gerson, Marvin [6 ]
机构：
[1] Univ Hlth Network, Toronto Gen Hosp, Div Infect Dis, Trop Dis Unit, Toronto, ON, Canada
[2] Univ Toronto, Dept Med, Toronto, ON, Canada
[3] Publ Hlth Ontario, Publ Hlth Ontario Labs, Toronto, ON, Canada
[4] Hosp Sick Children, Ctr Study Complex Childhood Dis, Toronto, ON M5G 1X8, Canada
[5] Univ Toronto, Sandra Rotman Ctr Global Hlth, Sandra A Rotman Labs, Toronto, ON M5S 1A1, Canada
[6] Humber River Hosp, N York, ON, Canada
来源：
TRAVEL MEDICINE AND INFECTIOUS DISEASE | 2015年 / 13卷 / 01期
关键词：
Drug resistance; Malabsorption; Malaria; Malarone; Plasmodium falciparum; TIME QUANTITATIVE PCR; GENE COPY NUMBER; PLASMODIUM-FALCIPARUM; GEOSENTINEL SURVEILLANCE; RETURNED TRAVELERS; TREATMENT POLICY; RESISTANCE; CHLOROQUINE; CHILDREN; DISEASES;
D O I：
10.1016/j.tmaid.2014.12.010
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Clinical failure of Malarone (TM) chemoprophylaxis is extremely rare. We report a case of Plasmodium falciparum malaria in a returned traveler to Ghana who fully adhered to atovaquone-proguanil (Malarone (TM)) chemoprophylaxis daily dosing, yet took the pills on an empty stomach. Screening of the P. falciparum isolate revealed triple codon mutation of Dhfr at positions 51, 59, and 108. Plasma drug levels of both atovaquone and proguanil revealed sub-therapeutic concentrations. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：89 / 93
页数：5
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