HIV and Age Do Not Substantially Interact in HIV-Associated Neurocognitive Impairment

被引：31

作者：

Cysique, Lucette A. ^{[1
]}

Maruff, Paul ^{[2
]}

Bain, Margaret P.

Wright, Edwina ^{[4
]}

Brew, Bruce J. ^{[3
,5
]}

机构：

[1] Univ New S Wales, Fac Med, Sydney, NSW 2052, Australia

[2] Univ Melbourne, Ctr Neurosci, Melbourne, Vic 3086, Australia

[3] St Vincents Hosp, Dept Neurol, St Vincents Ctr Appl Med Res, Darlinghurst, NSW 2010, Australia

[4] Alfred Hosp, Dept Infect Dis, Melbourne, Vic 3004, Australia

[5] St Vincents Hosp, St Vincents Ctr Appl Med Res, Dept Infect Dis, Darlinghurst, NSW 2010, Australia

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2011年 / 23卷 / 01期

关键词：

ACTIVE ANTIRETROVIRAL THERAPY; NEUROPSYCHOLOGICAL IMPAIRMENT; DEMENTIA; PREVALENCE; INFECTION;

D O I：

10.1176/appi.neuropsych.23.1.83

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors investigated the combined age and HIV effects on cognitive functions in 146 individuals, 116 of whom had HIV infection. Forty-two percent had HIV-associated neurocognitive disorder, and all were receiving highly active antiretroviral therapy. Using linear and nonlinear regression modeling, the authors found only a trending effect of the quadratic term HIV status X age, both including dementia cases (p=0.12) and excluding dementia cases (p<0.06). Our results suggest that either this early-2000 cohort is not old enough to detect a clear interactive age and HIV effect or that there may be a survivor bias for individuals with long-term infection. Further longitudinal studies are warranted. (The Journal of Neuropsychiatry and Clinical Neurosciences 2011; 23:83-89)

引用

页码：83 / 89

页数：7

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