Regulation between survival, persistence, and elimination of intracellular mycobacteria: a nested equilibrium of delicate balances

被引：30
作者：
Kumar, Dhiraj [1 ]
Rao, Kanury V. S. [1 ]
机构：
[1] Int Ctr Genet Engn & Biotechnol, Immunol Grp, New Delhi 110067, India
来源：
MICROBES AND INFECTION | 2011年 / 13卷 / 02期
关键词：
Mycobacterium tuberculosis; Autophagy; Lipid metabolism; Host-pathogen interactions; Systems biology; HOST IMMUNE-SYSTEM; DOUBLE-EDGED-SWORD; PHAGOSOME MATURATION; INFECTED MACROPHAGES; SIGNALING PATHWAYS; APOPTOTIC ENVELOPE; CELL BIOLOGY; TUBERCULOSIS; AUTOPHAGY; DISEASE;
D O I：
10.1016/j.micinf.2010.10.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This review elaborates on recent insights gained on the dynamic aspects of interactions between pathogen and the host intracellular machinery in tuberculosis infection. In addition we will also discuss the utility of adopting a systems biology approach, both for a better understanding of TB biology, and for the development of more effective ways for disease management. (c) 2010 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：121 / 133
页数：13
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