Comparative metagenomics of microbial communities

被引：1101

作者：

Tringe, SG

von Mering, C

Kobayashi, A

Salamov, AA

Chen, K

Chang, HW

Podar, M

Short, JM

Mathur, EJ

Detter, JC

Bork, P

Hugenholtz, P

Rubin, EM

机构：

[1] US DOE, Joint Genome Inst, Walnut Creek, CA 94598 USA

[2] Univ Calif Berkeley, Lawrence Berkeley Lab, Genom Div, Berkeley, CA 94720 USA

[3] European Mol Biol Lab, D-69117 Heidelberg, Germany

[4] Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA

[5] Diversa Corp, San Diego, CA 92121 USA

来源：

SCIENCE | 2005年 / 308卷 / 5721期

关键词：

D O I：

10.1126/science.1107851

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The species complexity of microbial communities and challenges in culturing representative isolates make it difficult to obtain assembled genomes. Here we characterize and compare the metabolic capabilities of terrestrial and marine microbial communities using largely unassembled sequence data obtained by shotgun sequencing DNA isolated from the various environments. Quantitative gene content analysis reveals habitat-specific fingerprints that reflect known characteristics of the sampled environments. The identification of environment-specific genes through a gene-centric comparative analysis presents new opportunities for interpreting and diagnosing environments.

引用

页码：554 / 557

页数：4

共 21 条

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