Quantitative analysis of aquaporin-4 antibody in longitudinally extensive transverse myelitis

被引：8
作者：
Wang, Jing [1 ]
Li, Xin [1 ]
Zhang, Da-Qi [1 ]
Yang, Chun-Sheng [1 ]
Qi, Yuan [1 ]
Li, Min-Shu [1 ]
Shi, Fu-Dong [1 ,2 ]
Yang, Li [1 ]
机构：
[1] Tianjin Med Univ, Gen Hosp, Tianjin Neurol Inst, Dept Neurol, Tianjin, Peoples R China
[2] St Josephs Hosp, Barrow Neurol Inst, Dept Neurol, Phoenix, AZ USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 278卷
基金：
中国国家自然科学基金;
关键词：
Longitudinally extensive transverse myelitis; Neuromyelitis optics spectrum disorders; Aquaporin-4; antibody; Fluorescence immunoprecipitation assay; Clinical features; NEUROMYELITIS-OPTICA; CLINICAL-FEATURES; NMO; IMMUNOPATHOGENESIS; DIAGNOSIS; MARKER;
D O I：
10.1016/j.jneuroim.2014.12.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Aquaporin-4 (AQP-4) antibody-positive longitudinally extensive transverse myelitis (LETM) is referred to as a neuromyelitis optica (NMO) spectrum disorder. We conducted an exploratory investigation of correlations between AQP-4 antibody serum levels, as determined by a fluorescent immunoprecipitation assay, and clinical characteristics in LETM. Expanded Disability Status Scores (EDSS) scores and number of segments of spinal cord involved were positively correlated to AQP-4 antibody levels. However, serum AQP-4 antibody levels were not correlated with the time to next attack or the conversion time of LETM to NMO, although seropositive LETM patients demonstrated a high conversion rate to NMO (78.1%). (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：26 / 29
页数：4
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