One-Pot Pseudo-Five-Component Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives via [DBU][OAc] as Ionic Liquid, and Their Anti-Cancer Evaluation and Molecular Modelling

被引：3

作者：

Kalpana, Kulkarni ^{[1
]}

Rani, V. Anitha ^{[2
]}

Kiran, B. Ravi ^{[1
]}

机构：

[1] Gokaraju Rangaraju Inst Engn & Technol, Dept Humanities & Sci Chem, Hyderabad 500090, India

[2] Inst Aeronaut Engn, Dept Chem, Hyderabad 500043, India

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2022年 / 92卷 / 06期

关键词：

DBU][OAc; environmentally benign synthesis; one-pot pseudo-five-component reaction; molecular docking; anticancer activity; molecular descriptors; INHIBITORS;

D O I：

10.1134/S1070363222060196

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives in the presence of eco-friendly ionic liquid [DBU][OAc] via a one-pot three-component environmentally benign reaction has been carried out. The multi-component reaction proceeds with initial formation of an isatoic anhydride from aromatic aldehydes and aromatic amines in [DBU][OAc] as ionic liquid medium at 70-75 degrees C with 85-90% yield. The products have been tested for cell viability against A549 and PC-3 cell lines. Among the tested products, compounds 4d and 4f demonstrate efficient cell toxicity. The target protein and ligand interactions have been modelled by molecular docking using AutoDockTools.

引用

页码：1070 / 1075

页数：6

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