One-Pot Pseudo-Five-Component Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives via [DBU][OAc] as Ionic Liquid, and Their Anti-Cancer Evaluation and Molecular Modelling

被引：3
作者：
Kalpana, Kulkarni [1 ]
Rani, V. Anitha [2 ]
Kiran, B. Ravi [1 ]
机构：
[1] Gokaraju Rangaraju Inst Engn & Technol, Dept Humanities & Sci Chem, Hyderabad 500090, India
[2] Inst Aeronaut Engn, Dept Chem, Hyderabad 500043, India
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2022年 / 92卷 / 06期
关键词：
DBU][OAc; environmentally benign synthesis; one-pot pseudo-five-component reaction; molecular docking; anticancer activity; molecular descriptors; INHIBITORS;
D O I：
10.1134/S1070363222060196
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives in the presence of eco-friendly ionic liquid [DBU][OAc] via a one-pot three-component environmentally benign reaction has been carried out. The multi-component reaction proceeds with initial formation of an isatoic anhydride from aromatic aldehydes and aromatic amines in [DBU][OAc] as ionic liquid medium at 70-75 degrees C with 85-90% yield. The products have been tested for cell viability against A549 and PC-3 cell lines. Among the tested products, compounds 4d and 4f demonstrate efficient cell toxicity. The target protein and ligand interactions have been modelled by molecular docking using AutoDockTools.
引用
收藏
页码：1070 / 1075
页数：6
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