An Approach to Nonsuppressed Testosterone in Transgender Women Receiving Gender-Affirming Feminizing Hormonal Therapy

被引:10
作者
Maheshwari, Arvind [1 ]
Nippoldt, Todd [1 ]
Davidge-Pitts, Caroline [1 ]
机构
[1] Mayo Clin, Div Endocrinol Diabet Metab & Nutr, 200 First St SW, Rochester, MN 55905 USA
关键词
transgender; hormones; testosterone; estrogen; anti-androgen; TRANSWOMEN; ESTROGENS;
D O I
10.1210/jendso/bvab068
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Nonsuppressed levels of testosterone are seen in up to a quarter of transgender women on gender-affirming feminizing hormonal treatment. Multiple factors contribute to this situation, including patient, medication, laboratory, and organ-specific concerns. We propose a stepwise approach to determine the etiology of nonsuppressed levels of testosterone in transgender women. This may lead to an appropriate feminizing hormonal therapy regimen and diagnosis of manageable medical conditions.
引用
收藏
页数:7
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共 27 条
  • [1] Cyproterone acetate or spironolactone in lowering testosterone concentrations for transgender individuals receiving oestradiol therapy
    Angus, Lachlan
    Leemaqz, Shalem
    Ooi, Olivia
    Cundill, Pauline
    Silberstein, Nicholas
    Locke, Peter
    Zajac, Jeffrey D.
    Cheung, Ada S.
    [J]. ENDOCRINE CONNECTIONS, 2019, 8 (07): : 935 - 940
  • [2] Low Free Testosterone Is Associated with Hypogonadal Signs and Symptoms in Men with Normal Total Testosterone
    Antonio, Leen
    Wu, Frederick C. W.
    O'Neill, Terence W.
    Pye, Stephen R.
    Ahern, Tomas B.
    Laurent, Michael R.
    Huhtaniemi, Ilpo T.
    Lean, Michael E. J.
    Keevil, Brian G.
    Rastrelli, Giulia
    Forti, Gianni
    Bartfai, Gyorgy
    Casanueva, Felipe F.
    Kula, Krzysztof
    Punab, Margus
    Giwercman, Aleksander
    Claessens, Frank
    Decallonne, Brigitte
    Vanderschueren, Dirk
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016, 101 (07) : 2647 - 2657
  • [3] Venous thrombo-embolism as a complication of cross-sex hormone treatment of male-to-female transsexual subjects: a review
    Asscheman, H.
    T'Sjoen, G.
    Lemaire, A.
    Mas, M.
    Meriggiola, M. C.
    Mueller, A.
    Kuhn, A.
    Dhejne, C.
    Morel-Journel, N.
    Gooren, L. J.
    [J]. ANDROLOGIA, 2014, 46 (07) : 791 - 795
  • [4] Testosterone Therapy in Men With Hypogonadism: An Endocrine Society* Clinical Practice Guideline
    Bhasin, Shalender
    Brito, Juan P.
    Cunningham, Glenn R.
    Hayes, Frances J.
    Hodis, Howard N.
    Matsumoto, Alvin M.
    Snyder, Peter J.
    Swerdloff, Ronald S.
    Wu, Frederick C.
    Yialamas, Maria A.
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2018, 103 (05) : 1715 - 1744
  • [5] Centers for Disease Control and Prevention, HOST VDSCP HORM VIT
  • [6] Breast Development in Transwomen After 1 Year of Cross-Sex Hormone Therapy: Results of a Prospective Multicenter Study
    de Blok, Christel Josefa Maria
    Klaver, Maartje
    Wiepjes, Chantal Maria
    Nota, Nienke Marije
    Heijboer, Annemieke Corine
    Fisher, Alessandra Daphne
    Schreiner, Thomas
    T'Sjoen, Guy
    den Heijer, Martin
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2018, 103 (02) : 532 - 538
  • [7] Effects of Cross-Sex Hormone Treatment on Transgender Women and Men
    Deutsch, Madeline B.
    Bhakri, Vipra
    Kubicek, Katrina
    [J]. OBSTETRICS AND GYNECOLOGY, 2015, 125 (03) : 605 - 610
  • [8] Doll EE, 2020, J ENDO SOC S1, V4, DOI [10.1210/jendso/bvaa046.2237, DOI 10.1210/JENDSO/BVAA046.2237]
  • [9] Unmasked Testicular Seminoma During Use of Hormonal Transgender Woman Therapy: A Hidden hCG-Secreting Tumor
    Elshimy, Ghada
    Tran, Kelvin
    Harman, Sherman M.
    Correa, Ricardo
    [J]. JOURNAL OF THE ENDOCRINE SOCIETY, 2020, 4 (07)
  • [10] Cyproterone acetate vs leuprolide acetate in combination with transdermal oestradiol in transwomen: a comparison of safety and effectiveness
    Gava, Giulia
    Cerpolini, Silvia
    Martelli, Valentina
    Battista, Giuseppe
    Seracchioli, Renato
    Meriggiola, Maria Cristina
    [J]. CLINICAL ENDOCRINOLOGY, 2016, 85 (02) : 239 - 246