Membrane-anchored peptide inhibits human immunodeficiency virus entry

被引：101
|
作者：
Hildinger, M
Dittmar, MT
Schult-Dietrich, P
Fehse, B
Schnierle, BS
Thaler, S
Stiegler, G
Welker, R
von Laer, D [1 ]
机构：
[1] Georg Speyer Haus, Paul Ehrlich Str 42-44, D-60596 Frankfurt, Germany
[2] Univ Hamburg, Heinrich Pette Inst Expt Virol & Immunol, D-20251 Hamburg, Germany
[3] Univ Hamburg, Krankenhaus Eppendorf, Zentrum Knochenmarktransplantat, D-20251 Hamburg, Germany
[4] Inst Appl Microbiol, A-1190 Vienna, Austria
来源：
JOURNAL OF VIROLOGY | 2001年 / 75卷 / 06期
关键词：
D O I：
10.1128/JVI.75.6.3038-3042.2001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Peptides derived from the heptad repeats of human immunodeficiency virus (HIV) gp41 envelope glycoprotein, such as T20, can efficiently inhibit HIV type 1 (HIV-1) entry. In this study, replication of HTV-1 was inhibited more than 100-fold in a T-helper cell line transduced with a retrovirus vector expressing membrane-anchored T20 on the cell surface. Inhibition was independent of coreceptor usage.
引用
收藏
页码：3038 / 3042
页数：5
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