Purpose Nuclear factor kappa B (NF-kappa B), a transcriptional factor that has been shown to be constitutively active in cervical cancer, is part of an important pathway leading to treatment resistance in many tumor types The pur pose of our study was to determine whether expression of NF kappa B in pretreatment specimens and specimens taken shortly after treatment initiation correlated with outcome in cervical cancer patients treated with definitive chemo-radiation Methods and Materials Eighteen patients with locally advanced cervical cancer were enrolled in a study in which cervical biopsy specimens were obtained before radiation therapy and 48 h after treatment initiation Matched biopsy specimens from 16 of these patients were available and evaluated for the nuclear expression of NF kappa B protein by immunohistochemical staining Results After a median follow up of 43 months, there were 9 total treatment failures Nuclear staining for NF kappa B was positive in 3 of 16 pretreatment biopsy specimens (19%) and 5 of 16 postradiation biopsy specimens (31%) Pretreatment expression of NF kappa B nuclear staining correlated with increased rates of local-regional failure (100% vs 23%,p = 001), distant failure (100% vs 38%,p = 0055), disease specific mortality (100% vs 31%, p = 003), and overall mortality (100% vs 38%,p = 0 055) Conclusions Our data suggest that pretreatment nuclear expression of NF kappa B may be associated with a poor outcome for cervical cancer patients treated with chemoradiation Although these data require validation in a larger group of patients, the results support the continued study of the relationship between NF kappa B and outcome in patients treated for carcinoma of the cervix (C) 2010 Elsevier Inc
机构:
Univ Manchester, Sch Math, Manchester M13 9PL, Lancs, EnglandSch Biol Sci, Ctr Cell Imaging, Liverpool L69 7ZB, Merseyside, England
Broomhead, David S.
Kell, Douglas B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Manchester, Sch Chem, Manchester Ctr Integrat Syst Biol, Manchester M1 7DN, Lancs, England
Univ Manchester, Manchester Interdisciplinary Bioctr, Manchester M1 7DN, Lancs, EnglandSch Biol Sci, Ctr Cell Imaging, Liverpool L69 7ZB, Merseyside, England
Kell, Douglas B.
Rand, David A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Warwick, Coventry CV4 7AL, W Midlands, EnglandSch Biol Sci, Ctr Cell Imaging, Liverpool L69 7ZB, Merseyside, England
Rand, David A.
See, Violaine
论文数: 0引用数: 0
h-index: 0
机构:
Sch Biol Sci, Ctr Cell Imaging, Liverpool L69 7ZB, Merseyside, EnglandSch Biol Sci, Ctr Cell Imaging, Liverpool L69 7ZB, Merseyside, England
See, Violaine
White, Michael R. H.
论文数: 0引用数: 0
h-index: 0
机构:
Sch Biol Sci, Ctr Cell Imaging, Liverpool L69 7ZB, Merseyside, EnglandSch Biol Sci, Ctr Cell Imaging, Liverpool L69 7ZB, Merseyside, England
机构:
Univ Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, SpainUniv Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, Spain
Espinosa, I.
Briones, J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, SpainUniv Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, Spain
Briones, J.
Bordes, R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, SpainUniv Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, Spain
Bordes, R.
Brunet, S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, SpainUniv Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, Spain
Brunet, S.
Martino, R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, SpainUniv Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, Spain
Martino, R.
Sureda, A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, SpainUniv Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, Spain
Sureda, A.
Sierra, J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, SpainUniv Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, Spain
Sierra, J.
Prat, J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Pathol, Barcelona 08025, SpainUniv Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, Spain
机构:
Univ Manchester, Sch Math, Manchester M13 9PL, Lancs, EnglandSch Biol Sci, Ctr Cell Imaging, Liverpool L69 7ZB, Merseyside, England
Broomhead, David S.
Kell, Douglas B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Manchester, Sch Chem, Manchester Ctr Integrat Syst Biol, Manchester M1 7DN, Lancs, England
Univ Manchester, Manchester Interdisciplinary Bioctr, Manchester M1 7DN, Lancs, EnglandSch Biol Sci, Ctr Cell Imaging, Liverpool L69 7ZB, Merseyside, England
Kell, Douglas B.
Rand, David A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Warwick, Coventry CV4 7AL, W Midlands, EnglandSch Biol Sci, Ctr Cell Imaging, Liverpool L69 7ZB, Merseyside, England
Rand, David A.
See, Violaine
论文数: 0引用数: 0
h-index: 0
机构:
Sch Biol Sci, Ctr Cell Imaging, Liverpool L69 7ZB, Merseyside, EnglandSch Biol Sci, Ctr Cell Imaging, Liverpool L69 7ZB, Merseyside, England
See, Violaine
White, Michael R. H.
论文数: 0引用数: 0
h-index: 0
机构:
Sch Biol Sci, Ctr Cell Imaging, Liverpool L69 7ZB, Merseyside, EnglandSch Biol Sci, Ctr Cell Imaging, Liverpool L69 7ZB, Merseyside, England
机构:
Univ Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, SpainUniv Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, Spain
Espinosa, I.
Briones, J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, SpainUniv Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, Spain
Briones, J.
Bordes, R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, SpainUniv Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, Spain
Bordes, R.
Brunet, S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, SpainUniv Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, Spain
Brunet, S.
Martino, R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, SpainUniv Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, Spain
Martino, R.
Sureda, A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, SpainUniv Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, Spain
Sureda, A.
Sierra, J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, SpainUniv Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, Spain
Sierra, J.
Prat, J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Pathol, Barcelona 08025, SpainUniv Autonoma Barcelona, Hosp Santa Crue & St Pau, Dept Clin Haematol, Barcelona 08025, Spain