EXPRESSION OF NUCLEAR TRANSCRIPTION FACTOR KAPPA B IN LOCALLY ADVANCED HUMAN CERVICAL CANCER TREATED WITH DEFINITIVE CHEMORADIATION

被引:24
作者
Garg, Amit K. [1 ]
Jhingran, Anuja
Klopf, Ann H.
Aggarwal, Bharat B. [2 ]
Kunnumakkara, Ajai B. [2 ]
Broadus, Russell R. [3 ]
Eifel, Patricia J.
Buchholz, Thomas A.
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Unit 97, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA
[3] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2010年 / 78卷 / 05期
关键词
Radiation; Chemotherapy; Cervical cancer; Nuclear transcription factor kappa B; CONCURRENT CHEMOTHERAPY; HUMAN-PAPILLOMAVIRUS; BREAST-CANCER; UP-REGULATION; FACTOR-KB; THERAPY; ACTIVATION; CARCINOMA; RADIATION; PATHWAY;
D O I
10.1016/j.ijrobp.2009.09.044
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose Nuclear factor kappa B (NF-kappa B), a transcriptional factor that has been shown to be constitutively active in cervical cancer, is part of an important pathway leading to treatment resistance in many tumor types The pur pose of our study was to determine whether expression of NF kappa B in pretreatment specimens and specimens taken shortly after treatment initiation correlated with outcome in cervical cancer patients treated with definitive chemo-radiation Methods and Materials Eighteen patients with locally advanced cervical cancer were enrolled in a study in which cervical biopsy specimens were obtained before radiation therapy and 48 h after treatment initiation Matched biopsy specimens from 16 of these patients were available and evaluated for the nuclear expression of NF kappa B protein by immunohistochemical staining Results After a median follow up of 43 months, there were 9 total treatment failures Nuclear staining for NF kappa B was positive in 3 of 16 pretreatment biopsy specimens (19%) and 5 of 16 postradiation biopsy specimens (31%) Pretreatment expression of NF kappa B nuclear staining correlated with increased rates of local-regional failure (100% vs 23%,p = 001), distant failure (100% vs 38%,p = 0055), disease specific mortality (100% vs 31%, p = 003), and overall mortality (100% vs 38%,p = 0 055) Conclusions Our data suggest that pretreatment nuclear expression of NF kappa B may be associated with a poor outcome for cervical cancer patients treated with chemoradiation Although these data require validation in a larger group of patients, the results support the continued study of the relationship between NF kappa B and outcome in patients treated for carcinoma of the cervix (C) 2010 Elsevier Inc
引用
收藏
页码:1331 / 1336
页数:6
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