Diterpenoid pyrones, novel blockers of the voltage-gated potassium channel Kv1,3 from fungal fermentations

被引：16
作者：
Goetz, MA [1 ]
Zink, DL [1 ]
Dezeny, G [1 ]
Dombrowski, A [1 ]
Polishook, JD [1 ]
Felix, JP [1 ]
Slaughter, RS [1 ]
Singh, SB [1 ]
机构：
[1] Merck & Co Inc, Merck Sharp & Dohme Res Labs, Rahway, NJ 07065 USA
来源：
TETRAHEDRON LETTERS | 2001年 / 42卷 / 07期
关键词：
D O I：
10.1016/S0040-4039(00)02258-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The isolation, structure elucidation and chemical modification of nalanthalide, a novel diterpenoid pyrone blocker of the voltage-gated potassium channel Kv1.3 are reported. The structure-activity relationship of the derivatives with respect to various associated biological activities is also discussed. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1255 / 1257
页数：3
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