New paradigms on hematopoietic stem cell differentiation

被引：152
作者：
Cheng, Hui [1 ,2 ,3 ,4 ,5 ]
Zheng, Zhaofeng [1 ,2 ,3 ,5 ]
Cheng, Tao [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Expt Hematol, Tianjin 300020, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Tianjin, Peoples R China
[3] Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin, Peoples R China
[4] Chinese Acad Med Sci, Ctr Stem Cell Med, Tianjin, Peoples R China
[5] Peking Union Med Coll, Dept Stem Cell & Regenerat Med, Tianjin, Peoples R China
来源：
PROTEIN & CELL | 2020年 / 11卷 / 01期
基金：
中国国家自然科学基金;
关键词：
hematopoietic stem cell; hierarchy; heterogeneity; differentiation; SELF-RENEWAL; BONE-MARROW; C-KIT; LINEAGE COMMITMENT; MYELOID PROGENITOR; IN-VIVO; MOUSE; IDENTIFICATION; MEGAKARYOCYTES; QUIESCENCE;
D O I：
10.1007/s13238-019-0633-0
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Ever since hematopoietic stem cells (HSCs) were first identified half a century ago, their differentiation roadmap has been extensively studied. The classical model of hematopoiesis has long held as a dogma that HSCs reside at the top of a hierarchy in which HSCs possess self-renewal capacity and can progressively give rise to all blood lineage cells. However, over the past several years, with advances in single cell technologies, this developmental scheme has been challenged. In this review, we discuss the evidence supporting heterogeneity within HSC and progenitor populations as well as the hierarchical models revised by novel approaches mainly in mouse system. These evolving views provide further understanding of hematopoiesis and highlight the complexity of hematopoietic differentiation.
引用
收藏
页码：34 / 44
页数：11
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