Blood Coagulation Testing Smartphone Platform Using Quartz Crystal Microbalance Dissipation Method

被引:15
|
作者
Yao, Jia [1 ,2 ]
Feng, Bin [1 ]
Zhang, Zhiqi [1 ]
Li, Chuanyu [1 ,3 ]
Zhang, Wei [1 ]
Guo, Zhen [1 ]
Zhao, Heming [2 ]
Zhou, Lianqun [1 ]
机构
[1] Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, CAS Key Lab Biomed Diagnost, Suzhou 215163, Peoples R China
[2] Soochow Univ, Sch Elect & Informat Engn, Suzhou 215006, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
blood coagulation; quartz crystal microbalance; dissipation; smartphone; point of care testing; QCM-D; WHOLE-BLOOD; VISCOELASTIC PROPERTIES; PROTHROMBIN TIME; ADSORPTION; PLASMA; SENSOR; BIOSENSOR; FREQUENCY; ACTIVATION;
D O I
10.3390/s18093073
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Blood coagulation function monitoring is important for people who are receiving anticoagulation treatment and a portable device is needed by these patients for blood coagulation self-testing. In this paper, a novel smartphone based blood coagulation test platform was proposed. It was developed based on parylene-C coated quartz crystal microbalance (QCM) dissipation measuring and analysis. The parylene-C coating constructed a robust and adhesive surface for fibrin capturing. The dissipation factor was obtained by measuring the frequency response of the sensor. All measured data were sent to a smartphone via Bluetooth for dissipation calculation and blood coagulation results computation. Two major coagulation indexes, activated partial thromboplastin time (APTT) and prothrombin time (PT) were measured on this platform compared with results by a commercial hemostasis system in a clinical laboratory. The measurement results showed that the adjusted R-square (R-2) value for APTT and PT measurements were 0.985 and 0.961 respectively. The QCM dissipation method for blood coagulation measurement was reliable and effective and the platform together with the QCM dissipation method was a promising solution for point of care blood coagulation testing.
引用
收藏
页数:12
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