blood coagulation;
quartz crystal microbalance;
dissipation;
smartphone;
point of care testing;
QCM-D;
WHOLE-BLOOD;
VISCOELASTIC PROPERTIES;
PROTHROMBIN TIME;
ADSORPTION;
PLASMA;
SENSOR;
BIOSENSOR;
FREQUENCY;
ACTIVATION;
D O I:
10.3390/s18093073
中图分类号:
O65 [分析化学];
学科分类号:
070302 ;
081704 ;
摘要:
Blood coagulation function monitoring is important for people who are receiving anticoagulation treatment and a portable device is needed by these patients for blood coagulation self-testing. In this paper, a novel smartphone based blood coagulation test platform was proposed. It was developed based on parylene-C coated quartz crystal microbalance (QCM) dissipation measuring and analysis. The parylene-C coating constructed a robust and adhesive surface for fibrin capturing. The dissipation factor was obtained by measuring the frequency response of the sensor. All measured data were sent to a smartphone via Bluetooth for dissipation calculation and blood coagulation results computation. Two major coagulation indexes, activated partial thromboplastin time (APTT) and prothrombin time (PT) were measured on this platform compared with results by a commercial hemostasis system in a clinical laboratory. The measurement results showed that the adjusted R-square (R-2) value for APTT and PT measurements were 0.985 and 0.961 respectively. The QCM dissipation method for blood coagulation measurement was reliable and effective and the platform together with the QCM dissipation method was a promising solution for point of care blood coagulation testing.
机构:
Zhejiang Univ, Inst Cyber Syst & Control, State Key Lab Ind Control Technol, Hangzhou 310027, Zhejiang, Peoples R ChinaZhejiang Univ, Inst Cyber Syst & Control, State Key Lab Ind Control Technol, Hangzhou 310027, Zhejiang, Peoples R China
Chen, Daqi
Zhang, Kaihuan
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机构:
Zhejiang Univ, Inst Cyber Syst & Control, State Key Lab Ind Control Technol, Hangzhou 310027, Zhejiang, Peoples R ChinaZhejiang Univ, Inst Cyber Syst & Control, State Key Lab Ind Control Technol, Hangzhou 310027, Zhejiang, Peoples R China
Zhang, Kaihuan
Zhou, Hui
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机构:
Yangzhou Univ, Sch Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R ChinaZhejiang Univ, Inst Cyber Syst & Control, State Key Lab Ind Control Technol, Hangzhou 310027, Zhejiang, Peoples R China
Zhou, Hui
Fan, Guokang
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h-index: 0
机构:
Yangzhou Univ, Sch Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R ChinaZhejiang Univ, Inst Cyber Syst & Control, State Key Lab Ind Control Technol, Hangzhou 310027, Zhejiang, Peoples R China
Fan, Guokang
Wang, You
论文数: 0引用数: 0
h-index: 0
机构:
Zhejiang Univ, Inst Cyber Syst & Control, State Key Lab Ind Control Technol, Hangzhou 310027, Zhejiang, Peoples R ChinaZhejiang Univ, Inst Cyber Syst & Control, State Key Lab Ind Control Technol, Hangzhou 310027, Zhejiang, Peoples R China
Wang, You
Li, Guang
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h-index: 0
机构:
Zhejiang Univ, Inst Cyber Syst & Control, State Key Lab Ind Control Technol, Hangzhou 310027, Zhejiang, Peoples R ChinaZhejiang Univ, Inst Cyber Syst & Control, State Key Lab Ind Control Technol, Hangzhou 310027, Zhejiang, Peoples R China
Li, Guang
Hu, Ruifen
论文数: 0引用数: 0
h-index: 0
机构:
Zhejiang Univ, Inst Cyber Syst & Control, State Key Lab Ind Control Technol, Hangzhou 310027, Zhejiang, Peoples R ChinaZhejiang Univ, Inst Cyber Syst & Control, State Key Lab Ind Control Technol, Hangzhou 310027, Zhejiang, Peoples R China
机构:
CIC biomaGUNE, Biosurfaces Unit, San Sebastian 20009, Spain
Max Planck Inst Met Res, Dept New Mat & Biosyst, D-70569 Stuttgart, GermanyClausthal Univ Technol, Inst Phys Chem, D-38678 Clausthal Zellerfeld, Germany