Porcine Deltacoronavirus Infection and Transmission in Poultry, United States

被引：156

作者：

Boley, Patricia A. ^{[1
,2
]}

Alhamo, Moyasar A. ^{[2
]}

Lossie, Geoffrey ^{[3
]}

Yadav, Kush Kumar ^{[2
]}

Vasquez-Lee, Marcia ^{[2
]}

Saif, Linda J. ^{[2
]}

Kenney, Scott P. ^{[2
]}

机构：

[1] Ohio State Univ, OARDC, Wooster, OH USA

[2] Ohio State Univ, Wooster, OH USA

[3] Ohio State Univ, Columbus, OH 43210 USA

来源：

EMERGING INFECTIOUS DISEASES | 2020年 / 26卷 / 02期

基金：

美国食品与农业研究所;

关键词：

EPIDEMIC DIARRHEA VIRUS; AMINOPEPTIDASE-N; GNOTOBIOTIC PIGS; CORONAVIRUS; PATHOGENICITY; PREVALENCE; STRAINS;

D O I：

10.3201/eid2602.190346

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Coronaviruses cause respiratory and gastrointestinal diseases in diverse host species. Deltacoronaviruses (DCoVs) have been identified in various songbird species and in leopard cats in China. In 2009, porcine deltacoronavirus (PDCoV) was detected in fecal samples from pigs in Asia, but its etiologic role was not identified until 2014, when it caused major diarrhea outbreaks in swine in the United States. Studies have shown that PDCoV uses a conserved region of the aminopeptidase N protein to infect cell lines derived from multiple species, including humans, pigs, and chickens. Because PDCoV is a potential zoonotic pathogen, investigations of its prevalence in humans and its contribution to human disease continue. We report experimental PDCoV infection and subsequent transmission among poultry. In PDCoV-inoculated chicks and turkey poults, we observed diarrhea, persistent viral RNA titers from cloaca) and tracheal samples, PDCoV-specific serum IgY antibody responses, and antigen-positive cells from intestines.

引用

页码：255 / 264

页数：10

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