FGF21 as a mediator of adaptive responses to stress and metabolic benefits of anti-diabetic drugs

被引：52
作者：
Kim, Kook Hwan [1 ]
Lee, Myung-Shik [1 ,2 ]
机构：
[1] Yonsei Univ, Coll Med, Severance Biomed Res Inst, Seoul 120752, South Korea
[2] Yonsei Univ, Coll Med, Dept Internal Med, Seoul 120752, South Korea
来源：
JOURNAL OF ENDOCRINOLOGY | 2015年 / 226卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
FGF21; stress; adaptation; metabolic disease; energy metabolism; GROWTH-FACTOR; 21; ACTIVATED-RECEPTOR-GAMMA; ENDOPLASMIC-RETICULUM STRESS; GLUCAGON-LIKE PEPTIDE-1; INHIBITS HEPATIC GLUCONEOGENESIS; FATTY LIVER-DISEASE; INSULIN SENSITIVITY; ENERGY-EXPENDITURE; PPAR-ALPHA; GLUCOSE-HOMEOSTASIS;
D O I：
10.1530/JOE-15-0160
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Most hormones secreted from specific organs of the body in response to diverse stimuli contribute to the homeostasis of the whole organism. Fibroblast growth factor 21 (FGF21), a hormone induced by a variety of environmental or metabolic stimuli, plays a crucial role in the adaptive response to these stressful conditions. In addition to its role as a stress hormone, FGF21 appears to function as a mediator of the therapeutic effects of currently available drugs and those under development for treatment of metabolic diseases. In this review, we highlight molecular mechanisms and the functional importance of FGF21 induction in response to diverse stress conditions such as changes of nutritional status, cold exposure, and exercise. In addition, we describe recent findings regarding the role of FGF21 in the pathogenesis and treatment of diabetes associated with obesity, liver diseases, pancreatitis, muscle atrophy, atherosclerosis, cardiac hypertrophy, and diabetic nephropathy. Finally, we discuss the current understanding of the actions of FGF21 as a crucial regulator mediating beneficial metabolic effects of therapeutic agents such as metformin, glucagon/glucagon-like peptide 1 analogues, thiazolidinedione, sirtuin 1 activators, and lipoic acid.
引用
收藏
页码：R1 / R16
页数：16
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