Facile Synthesis of 3-Substituted Isoquinolines Derivatives via Microwave-assisted Tandem Three-component Coupling Cyclization

被引：8
作者：
Lin Long [1 ]
Wu Qiongyou [1 ]
Huang Shaowei [1 ]
Yang Guangfu [1 ]
机构：
[1] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2012年 / 30卷 / 05期
基金：
中国国家自然科学基金;
关键词：
palladium; copper-catalyst; microwave; isoquinolines; tandem reaction; coupling cyclization; PALLADIUM-CATALYZED IMINOANNULATION; BIOLOGICAL EVALUATION; IRIDIUM COMPLEXES; NAPHTHYLISOQUINOLINE ALKALOIDS; PYRIDINES; RESOLUTION; LIGANDS; LIBRARY;
D O I：
10.1002/cjoc.201100560
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel three-component reaction of o-bromobenzaldehyde, terminal alkynes and tert-butyl amine has been established, which proceeded smoothly to give 3-substituted isoquinolines in good yields in the presence of palladium/copper catalysts under microwave irradiation.
引用
收藏
页码：1075 / 1082
页数：8
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