Novel enantiocomplementary C2-Symmetric chiral bis(imidazoline) ligands:: Highly enantioselective Friedel-Crafts alkylation of Indoles with ethyl 3,3,3-trifluoropyruvate

被引：111
作者：
Nakamura, Shuichi [1 ]
Hyodo, Kengo [1 ]
Nakamura, Yuko [1 ]
Shibata, Norio [1 ]
Toru, Takeshi [1 ]
机构：
[1] Nagoya Inst Technol, Dept Appl Chem, Grad Sch Engn, Showa Ku, Nagoya, Aichi 4668555, Japan
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2008年 / 350卷 / 10期
关键词：
asymmetric catalysis; Friedel-Crafts reaction; imidazolines; Lewis acids;
D O I：
10.1002/adsc.200800189
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Enantioselective Friedel-Crafts alkylations of a variety of indoles with ethyl 3,3,3-trifluoropyruvate catalyzed by novel chiral m-phenylenebis(imidazoline)-copper(II) complexes or the bis(imidazoline)-achiral acid combination afforded products with high enantioselectivity. Both enantiomers of indole derivatives can be prepared with high enantioselectivities by tuning the N-substituents of the imidazoline.
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页码：1443 / 1448
页数：6
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