Reflections on the system of evaluation of gene-edited livestock

被引:1
作者
Fan, Ziyao [1 ]
Wu, Tianwen [1 ]
Wu, Kui [1 ]
Mu, Yulian [1 ]
Li, Kui [1 ]
机构
[1] Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing 100193, Peoples R China
基金
中国博士后科学基金;
关键词
evaluation; gene editing; livestock; performance; safety; ZINC-FINGER NUCLEASES; GENOME; ENDONUCLEASE; CATTLE;
D O I
10.15302/J-FASE-2019303
中图分类号
S3 [农学(农艺学)];
学科分类号
0901 ;
摘要
The rapid development of biotechnology has provided a greater understanding of the biological functions of major candidate genes that have important functions regarding economic traits, and new materials for livestock breeding have been obtained through gene editing (GE) and embryo manipulation with the purpose of improving quality and output and reducing the costs and risk of disease. Public concerns, particularly over safety risks and production performance, must be addressed. Evaluation is the most important component of the regulation of gene-edited livestock and is a crucial guarantee of public safety before the marketing of gene-edited animal products. Here, the system of evaluation of gene-edited livestock is discussed in terms of public safety and production performance. The search for safe and ethical applications in the GE of livestock, a case-by-case evaluation strategy, and classification and simplification are used in order to promote a more efficient, objective, comprehensive and operable evaluation system.
引用
收藏
页码:211 / 217
页数:7
相关论文
共 33 条
[1]   Search-and-replace genome editing without double-strand breaks or donor DNA [J].
Anzalone, Andrew V. ;
Randolph, Peyton B. ;
Davis, Jessie R. ;
Sousa, Alexander A. ;
Koblan, Luke W. ;
Levy, Jonathan M. ;
Chen, Peter J. ;
Wilson, Christopher ;
Newby, Gregory A. ;
Raguram, Aditya ;
Liu, David R. .
NATURE, 2019, 576 (7785) :149-+
[2]   Enhancing gene targeting with designed zinc finger nucleases [J].
Bibikova, M ;
Beumer, K ;
Trautman, JK ;
Carroll, D .
SCIENCE, 2003, 300 (5620) :764-764
[3]   Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function [J].
Burkard, Christine ;
Lillico, Simon G. ;
Reid, Elizabeth ;
Jackson, Ben ;
Mileham, Alan J. ;
Ait-Ali, Tahar ;
Whitelaw, C. Bruce A. ;
Archibald, Alan L. .
PLOS PATHOGENS, 2017, 13 (02)
[4]   Production of hornless dairy cattle from genome-edited cell lines [J].
Carlson, Daniel F. ;
Lancto, Cheryl A. ;
Zang, Bin ;
Kim, Eui-Soo ;
Walton, Mark ;
Oldeschulte, David ;
Seabury, Christopher ;
Sonstegard, Tad S. ;
Fahrenkrug, Scott C. .
NATURE BIOTECHNOLOGY, 2016, 34 (05) :479-481
[5]   Efficient TALEN-mediated gene knockout in livestock [J].
Carlson, Daniel F. ;
Tan, Wenfang ;
Lillico, Simon G. ;
Stverakova, Dana ;
Proudfoot, Chris ;
Christian, Michelle ;
Voytas, Daniel F. ;
Long, Charles R. ;
Whitelaw, C. Bruce A. ;
Fahrenkrug, Scott C. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (43) :17382-17387
[6]   Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases [J].
Cho, Seung Woo ;
Kim, Sojung ;
Kim, Yongsub ;
Kweon, Jiyeon ;
Kim, Heon Seok ;
Bae, Sangsu ;
Kim, Jin-Soo .
GENOME RESEARCH, 2014, 24 (01) :132-141
[7]   Multiplex Genome Engineering Using CRISPR/Cas Systems [J].
Cong, Le ;
Ran, F. Ann ;
Cox, David ;
Lin, Shuailiang ;
Barretto, Robert ;
Habib, Naomi ;
Hsu, Patrick D. ;
Wu, Xuebing ;
Jiang, Wenyan ;
Marraffini, Luciano A. ;
Zhang, Feng .
SCIENCE, 2013, 339 (6121) :819-823
[8]   INTRODUCTION OF A RABBIT BETA-GLOBIN GENE INTO THE MOUSE GERM LINE [J].
COSTANTINI, F ;
LACY, E .
NATURE, 1981, 294 (5836) :92-94
[9]   Novel Features and Considerations for ERA and Regulation of Crops Produced by Genome Editing [J].
Duensing, Nina ;
Sprink, Thorben ;
Parrott, Wayne A. ;
Fedorova, Maria ;
Lema, Martin A. ;
Wolt, Jeffrey D. ;
Bartsch, Detlef .
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2018, 6
[10]   Improving CRISPR-Cas nuclease specificity using truncated guide RNAs [J].
Fu, Yanfang ;
Sander, Jeffry D. ;
Reyon, Deepak ;
Cascio, Vincent M. ;
Joung, J. Keith .
NATURE BIOTECHNOLOGY, 2014, 32 (03) :279-284