Longitudinal effects of cognitive behavioral therapy for depression on the neural correlates of emotion regulation

被引:29
作者
Rubin-Falcone, Harry [1 ,2 ]
Weber, Jochen [3 ]
Kishon, Ronit [1 ]
Ochsner, Kevin [3 ]
Delaparte, Lauren [4 ]
Dore, Bruce [5 ]
Zanderigo, Francesca [1 ,2 ]
Oquendo, Maria A. [6 ]
Mann, J. John [1 ,2 ]
Miller, Jeffrey M. [1 ,2 ]
机构
[1] Columbia Univ, Dept Psychiat, New York, NY USA
[2] New York State Psychiat Inst & Hosp, Div Mol Imaging & Neuropathol, New York, NY 10032 USA
[3] Columbia Univ, Dept Psychol, New York, NY 10027 USA
[4] SUNY Stony Brook, Dept Psychol, Stony Brook, NY 11794 USA
[5] Univ Penn, Annenberg Sch Commun, Philadelphia, PA 19104 USA
[6] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA
关键词
Cognitive behavioral therapy; CBT; Depression; MDD; Functional MRI; Emotion regulation; TREATMENT RESPONSE; PREDICTS RESPONSE; FMRI; REAPPRAISAL; ACTIVATION; FAILURE; PSYCHOTHERAPY; STIMULATION; MEDICATIONS; RECURRENCE;
D O I
10.1016/j.pscychresns.2017.11.002
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Cognitive behavioral therapy (CBT) is effective for a substantial minority of patients suffering from major depressive disorder (MDD), but its mechanism of action at the neural level is not known. As core techniques of CBT seek to enhance emotion regulation, we scanned 31 MDD participants prior to 14 sessions of CBT using functional magnetic resonance imaging (fMRI) and a task in which participants engaged in a voluntary emotion regulation strategy while recalling negative autobiographical memories. Eighteen healthy controls were also scanned. Twenty-three MDD participants completed post-treatment fMRI scanning, and 12 healthy volunteers completed repeat scanning without intervention. Better treatment outcome was associated with longitudinal enhancement of the emotion regulation-dependent BOLD contrast within subgenual anterior cingulate, medial prefrontal cortex, and lingual gyrus. Baseline emotion regulation-dependent BOLD contrast did not predict treatment outcome or differ between MDD and control groups. CBT response may be mediated by enhanced downregulation of neural activity during emotion regulation; brain regions identified overlap with those found using a similar task in a normative sample, and include regions related to self-referential and emotion processing. Future studies should seek to determine specificity of this downregulation to CBT, and evaluate it as a treatment target in MDD.
引用
收藏
页码:82 / 90
页数:9
相关论文
共 61 条
[11]   Evidence of successful modulation of brain activation and subjective experience during reappraisal of negative emotion in unmedicated depression [J].
Dillon, Daniel Gerard ;
Pizzagalli, Diego Andrea .
PSYCHIATRY RESEARCH-NEUROIMAGING, 2013, 212 (02) :99-107
[12]   Randomized trial of behavioral activation, cognitive therapy, and antidepressant medication in the prevention of relapse and recurrence in major depression [J].
Dobson, Keith S. ;
Dimidjian, Sona ;
Kohlenberg, Robert J. ;
Rizvi, Shireen L. ;
Dunner, David L. ;
Jacobson, Neil S. ;
Hollon, Steven D. ;
Schmaling, Karen B. ;
Gallop, Robert J. ;
Gollan, Jackie K. .
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY, 2008, 76 (03) :468-477
[13]   Cluster failure: Why fMRI inferences for spatial extent have inflated false-positive rates [J].
Eklund, Anders ;
Nichols, Thomas E. ;
Knutsson, Hans .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (28) :7900-7905
[14]  
ELKIN I, 1989, ARCH GEN PSYCHIAT, V46, P971
[15]  
First M.B., 1994, STRUCTURED CLIN INTE
[16]   Reward-related brain function as a predictor of treatment response in adolescents with major depressive disorder [J].
Forbes, Erika E. ;
Olino, Thomas M. ;
Ryan, Neal D. ;
Birmaher, Boris ;
Axelson, David ;
Moyles, Donna L. ;
Dahl, Ronald E. .
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE, 2010, 10 (01) :107-118
[17]   Does cognitive behavior therapy alter emotion regulation in inpatients with a depressive disorder? [J].
Forkmann, Thomas ;
Scherer, Anne ;
Pawelzik, Markus ;
Mainz, Verena ;
Drueke, Barbara ;
Boecker, Maren ;
Gauggel, Siegfried .
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT, 2014, 7 :147-153
[18]   Cognitive behavioural therapy for depression: systematic review of imaging studies [J].
Franklin, George ;
Carson, Alan J. ;
Welch, Killian A. .
ACTA NEUROPSYCHIATRICA, 2016, 28 (02) :61-74
[19]   Neural responses to sad facial expressions in major depression following cognitive behavioral therapy [J].
Fu, Cynthia H. Y. ;
Williams, Steven C. R. ;
Cleare, Anthony J. ;
Scott, Jan ;
Mitterschiffthaler, Martina T. ;
Walsh, Nicholas D. ;
Donaldson, Catherine ;
Suckling, John ;
Andrew, Chris ;
Steiner, Herbert ;
Murray, Robin M. .
BIOLOGICAL PSYCHIATRY, 2008, 64 (06) :505-512
[20]   Anterior cingulate volume predicts response to cognitive behavioral therapy in major depressive disorder [J].
Fujino, Junya ;
Yamasaki, Nobuyuki ;
Miyata, Jun ;
Sasaki, Hitoshi ;
Matsukawa, Noriko ;
Takemura, Ariyoshi ;
Tei, Shisei ;
Sugihara, Genichi ;
Aso, Toshihiko ;
Fukuyama, Hidenao ;
Takahashi, Hidehiko ;
Inoue, Kazuomi ;
Murai, Toshiya .
JOURNAL OF AFFECTIVE DISORDERS, 2015, 174 :397-399