A single nucleotide polymorphism in the metabotropic glutamate receptor 7 gene is associated with multiple sclerosis in Iranian population

被引：6

作者：

Mazdeh, Mehrdokht ^{[1
]}

Noroozi, Rezvan ^{[2
]}

Komaki, Alireza ^{[1
]}

Azari, Iman ^{[2
]}

Ghafouri-Fard, Soudeh ^{[2
]}

Taheri, Mohammad ^{[3
,4
]}

机构：

[1] Hamadan Univ Med Sci, Neurophysiol Res Ctr, Hamadan, Iran

[2] Shahid Beheshti Univ Med Sci, Dept Med Genet, Tehran, Iran

[3] Shahid Beheshti Univ Med Sci, Student Res Comm, Tehran, Iran

[4] Shahid Beheshti Univ Med Sci, Urogenital Stem Cell Res Ctr, Tehran, Iran

来源：

MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2019年 / 28卷

关键词：

GRM7; Glutamate receptor; Multiple sclerosis; LINKAGE; AUTISM;

D O I：

10.1016/j.msard.2019.01.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Glutamate excitotoxicity has been previously associated with development of multiple sclerosis (MS). The metabotropic glutamate receptor 7 (GRM7) gene is a G protein-coupled receptor that suppresses the cyclic AMP cascade after activation by glutamate. Single nucleotide polymorphisms (SNPs) within this gene have been reported to be associated with neuropsychiatric disorders. In the present study, we assessed associations between two intronic variants of GRM7 (rs6782011 and rs779867) and risk of MS in an Iranian population. The rs779867 was associated with MS risk in recessive model (OR (95% CI) = 0.67 (0.48-0.94)), P-value = 0.02, adjusted P-value = 0.04). There was no significant difference in allele and genotype frequencies of rs6782011 between cases and controls. None of the estimated haplotype blocks of rs6782011 and rs779867 were associated with MS risk in the assessed population. The current study provides some evidence for participation of GRM7 in the pathogenesis of MS and warrants further studies in larger sample sizes.

引用

页码：189 / 192

页数：4

共 21 条

[1] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].

Burton, Paul R. ;

Clayton, David G. ;

Cardon, Lon R. ;

Craddock, Nick ;

Deloukas, Panos ;

Duncanson, Audrey ;

Kwiatkowski, Dominic P. ;

McCarthy, Mark I. ;

Ouwehand, Willem H. ;

Samani, Nilesh J. ;

Todd, John A. ;

Donnelly, Peter ;

Barrett, Jeffrey C. ;

Davison, Dan ;

Easton, Doug ;

Evans, David ;

Leung, Hin-Tak ;

Marchini, Jonathan L. ;

Morris, Andrew P. ;

Spencer, Chris C. A. ;

Tobin, Martin D. ;

Attwood, Antony P. ;

Boorman, James P. ;

Cant, Barbara ;

Everson, Ursula ;

Hussey, Judith M. ;

Jolley, Jennifer D. ;

Knight, Alexandra S. ;

Koch, Kerstin ;

Meech, Elizabeth ;

Nutland, Sarah ;

Prowse, Christopher V. ;

Stevens, Helen E. ;

Taylor, Niall C. ;

Walters, Graham R. ;

Walker, Neil M. ;

Watkins, Nicholas A. ;

Winzer, Thilo ;

Jones, Richard W. ;

McArdle, Wendy L. ;

Ring, Susan M. ;

Strachan, David P. ;

Pembrey, Marcus ;

Breen, Gerome ;

St Clair, David ;

Caesar, Sian ;

Gordon-Smith, Katherine ;

Jones, Lisa ;

Fraser, Christine ;

Green, Elain K. .

NATURE, 2007, 447 (7145) :661-678

[2] GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans [J].

Chittoor, Geetha ;

Kent, Jack W., Jr. ;

Almeida, Marcio ;

Puppala, Sobha ;

Farook, Vidya S. ;

Cole, Shelley A. ;

Haack, Karin ;

Goering, Harald H. H. ;

MacCluer, Jean W. ;

Curran, Joanne E. ;

Carless, Melanie A. ;

Johnson, Matthew P. ;

Moses, Eric K. ;

Almasy, Laura ;

Mahaney, Michael C. ;

Lehman, Donna M. ;

Duggirala, Ravindranath ;

Comuzzie, Anthony G. ;

Blangero, John ;

Voruganti, Venkata Saroja .

BMC GENOMICS, 2016, 17

[3]

Cianfoni A, 2007, AM J NEURORADIOL, V28, P272

[4]

Cooper David N, 2010, Hum Genomics, V4, P284

[5] Biomarkers of Therapeutic Response in Multiple Sclerosis: Current Status [J].

Harris, Violaine K. ;

Sadiq, Saud A. .

MOLECULAR DIAGNOSIS & THERAPY, 2014, 18 (06) :605-617

[6] Genetic Variation at the FTO Locus Influences RBL2 Gene Expression [J].

Jowett, Jeremy B. M. ;

Curran, Joanne E. ;

Johnson, Matthew P. ;

Carless, Melanie A. ;

Goering, Harald H. H. ;

Dyer, Thomas D. ;

Cole, Shelley A. ;

Comuzzie, Anthony G. ;

MacCluer, Jean W. ;

Moses, Eric K. ;

Blangero, John .

DIABETES, 2010, 59 (03) :726-732

[7] Ionotropic and metabotropic glutamate receptor structure and pharmacology [J].

Kew, JNC ;

Kemp, JA .

PSYCHOPHARMACOLOGY, 2005, 179 (01) :4-29

[8] Association of GRM7 Variants with Different Phenotype Patterns of Age-Related Hearing Impairment in an Elderly Male Han Chinese Population [J].

Luo, Huajie ;

Yang, Tao ;

Jin, Xiaojie ;

Pang, Xiuhong ;

Li, Jiping ;

Chai, Yongchuan ;

Li, Lei ;

Zhang, Yi ;

Zhang, Luping ;

Zhang, Zhihua ;

Wu, Wenjing ;

Zhang, Qin ;

Hu, Xianting ;

Sun, Jingwen ;

Jiang, Xuemei ;

Fan, Zhuping ;

Huang, Zhiwu ;

Wu, Hao .

PLOS ONE, 2013, 8 (10)

[9] Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts [J].

Muglia, P. ;

Tozzi, F. ;

Galwey, N. W. ;

Francks, C. ;

Upmanyu, R. ;

Kong, X. Q. ;

Antoniades, A. ;

Domenici, E. ;

Perry, J. ;

Rothen, S. ;

Vandeleur, C. L. ;

Mooser, V. ;

Waeber, G. ;

Vollenweider, P. ;

Preisig, M. ;

Lucae, S. ;

Mueller-Myhsok, B. ;

Holsboer, F. ;

Middleton, L. T. ;

Roses, A. D. .

MOLECULAR PSYCHIATRY, 2010, 15 (06) :589-601

[10] Glutamate receptor expression in multiple sclerosis lesions [J].

Newcombe, Jia ;

Uddin, Alim ;

Dove, Rosamund ;

Patel, Bela ;

Turski, Lechoslaw ;

Nishizawa, Yukio ;

Smith, Terence .

BRAIN PATHOLOGY, 2008, 18 (01) :52-61

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