Insulin-degrading enzyme in the Alzheimer's disease brain:: prominent localization in neurons and senile plaques

被引：98

作者：

Bernstein, HG

Ansorge, S

Riederer, P

Reiser, M

Frölich, L

Bogerts, B

机构：

[1] Univ Magdeburg, Dept Psychiat, D-39120 Magdeburg, Germany

[2] Univ Magdeburg, Dept Expt Immunol, D-39120 Magdeburg, Germany

[3] Univ Wurzburg, Clin Neurochem Dept Psychiat, D-8700 Wurzburg, Germany

[4] Univ Magdeburg, Fac Med, Inst Med Neurobiol, D-39120 Magdeburg, Germany

[5] Goethe Univ Frankfurt, Dept Psychiat 1, D-6000 Frankfurt, Germany

来源：

NEUROSCIENCE LETTERS | 1999年 / 263卷 / 2-3期

关键词：

insulin-degrading enzyme; human brain; Alzheimer disease; amyloid beta-protein;

D O I：

10.1016/S0304-3940(99)00135-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The anatomical distribution of insulin-degrading enzyme (IDE) was studied in normal and Alzheimer's disease (AD) human brains. By use of a monospecific, polyclonal antiserum against the enzyme we identified IDE antigen in multiple cortical and subcortical neurons. Glia did not show IDE immunoreactivity. In AD brains immunostaining appeared stronger than in controls and appeared not only in neurons but also in senile plaques. In a probable case of Lewy body variant of AD Lewy bodies in neurons of the Nuc. basalis of Meynert were immunopositive for IDE. Our anatomical data suggest that the enzyme is associated with typical neuropathologic hallmarks of AD and its expression appears up-regulated in some brain areas. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：161 / 164

页数：4

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