MeCP2 inhibits proliferation and migration of breast cancer via suppression of epithelial-mesenchymal transition

被引：13

作者：

Jiang, Wei ^{[1
]}

Liang, Yan-Ling ^{[2
]}

Liu, Yang ^{[1
]}

Chen, Yu-Yan ^{[1
]}

Yang, Shu-Ting ^{[1
]}

Li, Bi-Rong ^{[1
]}

Yu, Ying-Xian ^{[1
]}

Lyu, Yansi ^{[3
]}

Wang, Rikang ^{[4
]}

机构：

[1] Shenzhen Univ, Sch Basic Med Sci, Dept Anat & Histol, Hlth Sci Ctr, Shenzhen, Peoples R China

[2] Nanhai Hosp, Guangdong Prov Peoples Hosp, Foshan, Peoples R China

[3] Shenzhen Univ, Dept Dermatol, Gen Hosp, Shenzhen, Peoples R China

[4] Jiangxi Univ Tradit Chinese Med, Natl Pharmaceut Engn Ctr Solid Preparat Chinese H, Nanchang 330006, Jiangxi, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2020年 / 24卷 / 14期

关键词：

breast cancer; epithelial-mesenchymal transition (EMT); invasion; Methyl-CpG-binding protein 2 (MeCP2); EXPRESSION; DNA; METASTASIS; INVASION; BINDING; EMT; METHYLATION;

D O I：

10.1111/jcmm.15428

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Methyl-CpG-binding protein 2 (MeCP2) is an important epigenetic regulator for normal neuronal maturation and brain glial cell function. Additionally, MeCP2 is also involved in a variety of cancers, such as breast, prostate, lung, liver and colorectal. However, whether MeCP2 contributes to the progression of breast cancer remains unknown. In the present study, we investigated the role of MeCP2 in cell proliferation, migration and invasion in vitro. We found that knockdown of MeCP2 inhibited expression of epithelial-mesenchymal transition (EMT)-related markers in breast cancer cell lines. In conclusion, our study suggests that MeCP2 inhibits proliferation and invasion through suppression of the EMT pathway in breast cancer.

引用

页码：7959 / 7967

页数：9

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