More Effective Nanomedicines through Particle Design

被引：366

作者：

Wang, Jin ^{[1
]}

Byrne, James D. ^{[1
]}

Napier, Mary E. ^{[1
]}

DeSimone, Joseph M. ^{[1
,2
,3
,4
]}

机构：

[1] Univ N Carolina, Dept Chem, Lineberger Comprehens Canc Ctr, Carolina Ctr Canc Nanotechnol Excellence, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Pharmacol, Inst Adv Mat, Inst Nanomed, Chapel Hill, NC 27599 USA

[3] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA

[4] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst Canc Res, New York, NY 10021 USA

来源：

SMALL | 2011年 / 7卷 / 14期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

GPI-ANCHORED PROTEINS; TARGETED DELIVERY; TRANSFERRIN RECEPTOR; GOLD NANOPARTICLES; SOLID TUMORS; HIGH-DENSITY; IN-VIVO; CELLULAR INTERNALIZATION; INTRACELLULAR DELIVERY; STEALTH NANOPARTICLES;

D O I：

10.1002/smll.201100442

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanomedicine is an emerging field that applies concepts in nanotechnology to develop novel diagnostics and therapies. Physical and chemical properties of particles, including size, shape, modulus, surface charge and surface chemistry, play an important role in determining particle-cell interactions, cellular trafficking mechanisms, biodistribution, and pharmacokinetics. This discussion focuses on both nanoparticles and microparticles since microparticles can also provide many insights for the development of drug carriers and possess advantages over nanoparticles in certain applications. This review covers recent major advancement in the nanomedicine field and also highlights studies using the PRINT technology.

引用

页码：1919 / 1931

页数：13

共 138 条

[1] Mechanisms of phagocytosis in macrophages [J].