Enabling Metallophotoredox Catalysis in Parallel Solution-Phase Synthesis Using Disintegrating Reagent Tablets

被引：6

作者：

Borlinghaus, Niginia ^{[1
]}

Schoenfeld, Barbara ^{[2
]}

Heitz, Stephanie ^{[1
]}

Klee, Johanna ^{[1
]}

Vukelic, Stella ^{[1
]}

Braje, Wilfried M. ^{[1
]}

Jolit, Anais ^{[1
]}

机构：

[1] AbbVie Deutschland GmbH & Co KG, Med Chem Dept, Neurosci Discovery Res, D-67061 Ludwigshafen, Germany

[2] AbbVie Deutschland GmbH & Co KG, NCE Formulat Sci, D-67061 Ludwigshafen, Germany

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 23期

关键词：

SINGLE-ELECTRON TRANSMETALATION; PHOTOREDOX; AMINATION; ARENES; TRIFLUOROMETHYLATION; PHOTOCATALYST; PARAFFIN; HALIDES;

D O I：

10.1021/acs.joc.1c01867

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Compressed tablets containing a mixture of a photocatalyst, a nickel catalyst, an inorganic base, and an inert excipient are employed as a fast, safe, and user-friendly chemical delivery system for two different metallophotoredox-catalyzed reactions. This delivery method simplifies the preparation of compound libraries using photoredox chemistry in a parallel setting. The reagent tablets were successfully applied to late-stage functionalization of drug-like intermediates. These tablets can be prepared with various reagents and catalysts in different sizes and be stored on the bench thanks to blister packaging.

引用

页码：16535 / 16547

页数：13

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