Potential protective effects of polysaccharide extracted from Ulva lactuca against male reprotoxicity induced by thiacloprid

被引：24

作者：

Kammoun, Intissar ^{[1
,2
]}

Bkhairia, Intidhar ^{[3
]}

Ben Abdallah, Fatma ^{[4
]}

Jaballi, Imen ^{[1
,5
]}

Ktari, Naourez ^{[3
]}

Boudawara, Ons ^{[6
]}

Nasri, Moncef ^{[3
]}

Gharsallah, Neji ^{[2
]}

Hakim, Ahmed ^{[5
]}

Ben Amara, Ibtissem ^{[1
]}

机构：

[1] Higher Inst Biotechnol Sfax, Unit Funct Genom & Plant Physiol, POB 261, Sfax 3038, Tunisia

[2] Univ Sfax, Sci Fac Sfax, Lab Biotechnol Appl Culture Improvement Plants LR, Sfax, Tunisia

[3] Univ Sfax, Natl Engn Sch Sfax, Lab Enzyme Engn & Microbiol, Sfax, Tunisia

[4] Univ Sfax, Fac Med Sfax, Lab Histol Embryol & Reprod Biol, Sfax, Tunisia

[5] Univ Sfax, Lab Pharmacol, Fac Med, Sfax, Tunisia

[6] Univ Sfax, Lab Anatomopathol, CHU Habib Bourguiba, Sfax, Tunisia

来源：

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2017年 / 123卷 / 05期

关键词：

Thiacloprid; polysaccharide; Ulva lactuca; testicles; oxidative stress; ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS; LIPID-PEROXIDATION; COMMERCIAL FORMULATIONS; SUPEROXIDE-DISMUTASE; SPERM; DELTAMETHRIN; GENOTOXICITY; CYPERMETHRIN; INSECTICIDE;

D O I：

10.1080/13813455.2017.1347686

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Context: Polysaccharides (PSs) from seaweeds have been reported to possess biological activity of potential medicinal values. Objective: The current study was conducted to establish the protective effects of PS extracted from Ulva lactuca against oxidative stress induced by Thiacloprid (THC) in the rat reproductive system. Materials and methods: Rats were exposed either to THC, THC+PS (100mg/kg), or THC+PS (200mg/kg). Results: Our study showed that THC induced severe disorders in the functional sperm parameters. A decrease in antioxidant activities and their genes expression were observed in the same group, compared to the controls. Our molecular data showing also a severe DNA breakdown in the testis of THC treated group. Moreover, THC treated group showed severe histopathological changes. Conclusions: Our results revealed that PS extracted from Ulva lactuca alleviated the THC induced reprotoxicity and reduced oxidative stress damages, DNA breakdown and histological injuries in the testis.

引用

页码：334 / 343

页数：10

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