Orthopaedic gene therapy using recombinant adeno-associated virus vectors

被引：10
作者：
Ke, J. [1 ,2 ,3 ,4 ]
Zheng, L. W. [1 ]
Cheung, L. K. [1 ]
机构：
[1] Univ Hong Kong, Fac Dent, Discipline Oral & Maxillofacial Surg, Sai Ying Pun, Hong Kong, Peoples R China
[2] Wuhan Univ, Key Lab Oral Biomed Engn, Minist Educ, Wuhan 430072, Hubei, Peoples R China
[3] Wuhan Univ, Dept Oral & Maxillofacial Surg, Sch Stomatol, Wuhan 430072, Hubei, Peoples R China
[4] Wuhan Univ, Hosp Stomatol, Wuhan 430072, Hubei, Peoples R China
来源：
ARCHIVES OF ORAL BIOLOGY | 2011年 / 56卷 / 07期
关键词：
Gene therapy; Recombinant adeno-associated virus 2; Bone; Cartilage; Tendon; MESENCHYMAL STEM-CELLS; INTERLEUKIN-1 RECEPTOR ANTAGONIST; HEPARAN-SULFATE PROTEOGLYCAN; ARTICULAR-CARTILAGE DEFECT; ADENO-ASSOCIATED VIRUS; GROWTH-FACTOR GENE; IN-VIVO; IMMUNE-RESPONSES; VIRAL VECTORS; AAV VECTORS;
D O I：
10.1016/j.archoralbio.2010.12.010
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Use of recombinant adeno-associated virus (rAAV) vectors is increasingly gaining popularity in gene therapy because of their desirable properties, including lack of pathogenicity, efficient transduction of dividing and non-dividing cells, and sustained maintenance of the viral genome. It is these features of rAAV vectors that made them the focus for gene-based therapy of skeletal tissue regeneration. This review outlines the biological characteristics of adeno-associated virus (AAV), states the biological processing as well as current advances of rAAV vectors, and describes the recent achievements of their applications in orthopaedic and craniofacial surgery. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：619 / 628
页数：10
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