Determining the role of microRNAs in psychiatric disorders

被引：247
作者：
Issler, Orna [1 ,2 ]
Chen, Alon [1 ,2 ]
机构：
[1] Weizmann Inst Sci, Dept Neurobiol, Ruhman Family Lab Res Neurobiol Stress, IL-76100 Rehovot, Israel
[2] Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, D-80804 Munich, Germany
来源：
NATURE REVIEWS NEUROSCIENCE | 2015年 / 16卷 / 04期
基金：
欧洲研究理事会; 以色列科学基金会;
关键词：
DORSOLATERAL PREFRONTAL CORTEX; NATIONAL COMORBIDITY SURVEY; MAJOR DEPRESSION; MOUSE MODEL; FUNCTIONAL CONNECTIVITY; NONCODING RNAS; COCAINE INTAKE; CHRONIC STRESS; RETT-SYNDROME; LIFE EVENTS;
D O I：
10.1038/nrn3879
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Recent studies have revealed that patients with psychiatric disorders have altered microRNA (miRNA) expression profiles in the circulation and brain. Furthermore, animal studies have shown that manipulating the levels of particular mi-RNAs in the brain can alter behaviour. Here, we review recent studies in humans, animal models, cellular systems and bioinformatics that have advanced our understanding of the contribution of brain mi-RNAs to the regulation of behaviour in the context of psychiatric conditions. These studies highlight the potential of miRNA levels to be used in the diagnosis of psychiatric disorders and suggest that brain mi-RNAs could become novel treatment targets for psychiatric disorders.
引用
收藏
页码：201 / 212
页数：12
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