Radiosynthesis of a new PSMA targeting ligand ([18F]FPy-DUPA-Pep)

被引：29

作者：

Malik, Noeen ^{[1
]}

Machulla, Hans-Juergen ^{[1
]}

Solbach, Christoph ^{[1
]}

Winter, Gordon ^{[1
]}

Reske, Sven N. ^{[1
]}

Zlatopolskiy, Boris ^{[1
]}

机构：

[1] Univ Hosp, Clin Nucl Med, Ulm, Germany

来源：

APPLIED RADIATION AND ISOTOPES | 2011年 / 69卷 / 07期

关键词：

Radiosynthesis; F-18]FPy-DUPA-Pep; PSMA targeting ligand; MEMBRANE ANTIGEN; N-SUCCINIMIDYL;

D O I：

10.1016/j.apradiso.2011.03.041

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Due to the specificity of expression of PSMA (prostate specific membrane antigen) particularly in prostate cancer cells (e.g. LNCaP), numerous PSMA ligands have been synthesized until now. In the current study, we synthesized DUPA-Pep having 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid (DUPA) linked via 8-aminooctanoic acid to two phenylalanine residues and chose 6-[F-18]fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester [F-18]FPy-TFP as a prosthetic group for coupling. [F-18]FPy-DUPA-Pep was obtained in a radiochemical yield of 48 +/- 0.9% (decay uncorrected) within 50 min with a chemical purity of > 98%. (C) 2011 Elsevier Ltd. All rights reserved.

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页码：1014 / 1018

页数：5

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