Interactions between Innate Lymphoid Cells and Cells of the Innate and Adaptive Immune System

被引：40

作者：

Symowski, Cornelia

Voehringer, David ^{[1
]}

机构：

[1] Univ Hosp Erlangen, Dept Infect Biol, Erlangen, Germany

来源：

FRONTIERS IN IMMUNOLOGY | 2017年 / 8卷

关键词：

allergic inflammation; helminths; mast cells; innate lymphoid cells; eosinophils; basophils; Th2; cells; alternatively activated macrophages; ALTERNATIVELY ACTIVATED MACROPHAGES; NATURAL HELPER-CELLS; LUNG INFLAMMATION; TYPE-2; IMMUNITY; AIRWAY INFLAMMATION; IL-33; PROMOTES; RESPONSES; EOSINOPHILS; EXPRESSION;

D O I：

10.3389/fimmu.2017.01422

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type 2 innate lymphoid cells (ILC2s) are a major source of cytokines, which are also produced by Th2 cells and several cell types of the innate immune system. Work over the past few years indicates that ILC2s play a central role in regulating type 2 immune responses against allergens and helminths. ILC2s can interact with a variety of cells types of the innate and adaptive immune system by cell-cell contacts or by communication via soluble factors. In this review, we provide an overview about recent advances in our understanding how ILC2s orchestrate type 2 immune responses with focus on direct interactions between ILC2s and other cells of the immune system.

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页数：8

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