Mild Traumatic Brain Injury Is Related to Elevated Cerebrospinal Fluid Tau in Alzheimer's Disease Dementia

被引：2

作者：

LoBue, Christian ^{[1
,2
]}

Kelley, Brendan J. ^{[3
]}

Hart, John ^{[1
,3
,4
]}

Helphrey, Jessica ^{[1
]}

Schaffert, Jeff ^{[1
]}

Cullum, C. Munro ^{[1
,2
,3
]}

Peters, Matthew E. ^{[5
]}

Douglas, Peter M. ^{[6
]}

机构：

[1] Univ Texas Southwestern Med Ctr Dallas, Dept Psychiat, Dallas, TX USA

[2] Univ Texas Southwestern Med Ctr Dallas, Dept Neurol Surg, Dallas, TX 75390 USA

[3] Univ Texas Southwestern Med Ctr Dallas, Dept Neurol, Dallas, TX USA

[4] Univ Texas Dallas, Sch Behav & Brain Sci, Dallas, TX USA

[5] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA

[6] Univ Texas Southwestern Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2022年 / 87卷 / 04期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

Biomarkers; concussion; dementia; neurodegeneration; risk factor; tau formation; traumatic brain injury; OLDER-ADULTS; EARLIER AGE; HISTORY; ONSET; BIOMARKERS; PATHOLOGY; RISK;

D O I：

10.3233/JAD-220112

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Few studies have examined an association between mild traumatic brain injury (mTBI) and Alzheimer's disease (AD). For this reason, we compared an AD dementia group with an mTBI history (n = 10) to a matched AD control group (n = 20) on measures of cognitive function, cerebral glucose metabolism, and markers of amyloid and tau deposition. Only a trend and medium-to-large effect size for higher phosphorylated and total tau was identified for the mTBI group. A history of mTBI may be associated with greater tau in AD, indicating a potential pathway for increasing risk for AD, though further evaluation with larger samples is needed.

引用

页码：1491 / 1496

页数：6

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