Biomaterial microlasers implantable in the cornea, skin, and blood

被引：71

作者：

Humar, Matjaz ^{[1
,2
,3
]}

Dobravec, Anja ^{[1
]}

Zhao, Xiangwei ^{[4
]}

Yun, Seok Hyun ^{[3
,5
]}

机构：

[1] J Stefan Inst, Condensed Matter Dept, Jamova 39, SI-1000 Ljubljana, Slovenia

[2] Univ Ljubljana, Fac Math & Phys, Jadranska 19, SI-1000 Ljubljana, Slovenia

[3] Harvard Med Sch, Massachusetts Gen Hosp, Wellman Ctr Photomed, 65 Landsdowne St UP-5, Cambridge, MA 02139 USA

[4] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China

[5] Harvard MIT Hlth Sci & Technol, 77 Massachusetts Ave Cambridge, Cambridge, MA 02139 USA

来源：

OPTICA | 2017年 / 4卷 / 09期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

DISTRIBUTED-FEEDBACK LASER; LIQUID-CRYSTALS; OPTOFLUIDIC LASERS; CELLS; MICROSPHERES; SENSORS;

D O I：

10.1364/OPTICA.4.001080

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Fluorescent stand-alone laser particles that are implantable into biological tissues have the potential to enable novel optical imaging, diagnosis, and therapy. Here we demonstrate several types of biocompatible microlasers and their lasing action within biological systems. Dye-doped polystyrene beads were embedded in the cornea and optically pumped to generate narrowband emission. We fabricated microbeads with poly(lactic-co-glycolic acid) and poly(lactic acid)-substances approved for medical use-and demonstrate lasing from within tissues and whole blood. Furthermore, we demonstrate biocompatible cholesterol-derivative microdroplet lasers via self-assembly to an onion-like radially resonant photonic crystal structure. These types of implanted lasers may enable real-time monitoring of physiological information, such as temperature. (C) 2017 Optical Society of America

引用

页码：1080 / 1085

页数：6

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