Benzimidazoles and benzoxazoles via the nucleophilic addition of anilines to nitroalkanes

被引：53

作者：

Aksenov, Alexander V. ^{[1
]}

Smirnov, Alexander N. ^{[1
]}

Aksenov, Nicolai A. ^{[1
]}

Bijieva, Asiyat S. ^{[1
]}

Aksenova, Inna V. ^{[1
]}

Rubin, Michael ^{[1
,2
]}

机构：

[1] North Caucasus Fed Univ, Dept Chem, Stavropol 355009, Russia

[2] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 14期

基金：

俄罗斯基础研究基金会;

关键词：

NON-HODGKINS-LYMPHOMA; 3-SUBSTITUTED; 2-QUINOLONES; BIOLOGICAL EVALUATION; POLYPHOSPHORIC ACID; COMPLEXES; DERIVATIVES; LIGANDS; TELMISARTAN; BENZOTHIAZOLES; ACETAMINATION;

D O I：

10.1039/c5ob00131e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

PPA-induced umpolung triggers efficient nucleophilic addition of unactivated anilines to nitroalkanes to produce N-hydroxyimidamides. The latter undergo sequential acid-promoted cyclocondensation with ortho-OH or ortho-NHR moieties to afford benzoxazoles and benzimidazoles, respectively.

引用

页码：4289 / 4295

页数：7

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