Recent Advances in Senotherapeutics Delivery

被引：0

作者：

Choi, Ji Young ^{[1
,2
]}

Yee, Samantha F. ^{[1
]}

Tchangalova, Tzvetelina ^{[1
]}

Yang, Guang ^{[1
]}

Fisher, John P. ^{[1
,2
,3
]}

机构：

[1] Univ Maryland, A James Clark Sch Engn, Fischell Dept Bioengn, Tissue Engn & Biomat Lab, College Pk, MD USA

[2] Univ Maryland, NIH Ctr Engn Complex Tissues, NIBIB, College Pk, MD USA

[3] Univ Maryland, A James Clark Sch Engn, Fischell Dept Bioengn, Tissue Engn & Biomat Lab, 4102A A James Clark Hall,8278 Paint Branch Dr, College Pk, MD 20742 USA

来源：

TISSUE ENGINEERING PART B-REVIEWS | 2022年 / 28卷 / 06期

关键词：

cellular senescence; senolytic; senomorphic; senotherapeutics; drug delivery; tissue-engineered models; CELLULAR SENESCENCE; POSTTRAUMATIC OSTEOARTHRITIS; PHOSPHOLIPID COMPLEX; CELLS; CURCUMIN; NAVITOCLAX; IDENTIFICATION; CONTRIBUTES; SUPPRESSION; DYSFUNCTION;

D O I：

10.1089/ten.teb.2021.0212

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Accumulation of senescent cells (SnCs) in various tissue types has been connected to an occurrence of different age-related diseases that are indicated by its own tissue-specific hallmarks Discovery of novel senolytic compounds that target major cellular mechanisms to inhibit the level of SnCs within the specific tissues or organs has been an emerging field in the age-related disease research. Although the positive effect of senolytics in global suppression of SnCs has been well studied in the past, effective tissue-specific delivery strategy of senotherapeutics before clinical application needs to be further investigated. In this review, we discuss the latest biological insights to currently available senotherapeutic options and explore the impactful in vitro tissue-engineered models possibly as a testbed for replicable testing of tissue-specific potency of senolytics.

引用

页码：1223 / 1234

页数：12

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