Statistical thermodynamic approach for evaluating the writhe transformations in circular DNAs

被引：10
作者：
Anselmi, C
Bocchinfuso, G
De Santis, P
Fuà, M
Scipioni, A
Savino, M
机构：
[1] Univ Rome La Sapienza, Fdn Cenci Bolognetti, Ist Pasteur, Dipartimento Chim, I-00185 Rome, Italy
[2] Univ Rome La Sapienza, Fdn Cenci Bolognetti, Ist Pasteur, Dipartimento Genet & Biol Mol, I-00185 Rome, Italy
来源：
JOURNAL OF PHYSICAL CHEMISTRY B | 1998年 / 102卷 / 29期
关键词：
D O I：
10.1021/jp981552v
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The model we advanced in a previous paper about DNA circularization (J. Phys. Chem. 1996, 100, 9968-9976), is extended to the sequence-dependent equilibrium between relaxed and supercoiled forms of circular DNAs. In the framework of first-order elasticity, we evaluate the canonical ensemble partition function and the related thermodynamic properties in terms of continuous variations of writhing and linking numbers, giving an estimate of the writhe transitions. The comparison with the Monte Carlo results is very significant. It convincingly proves the validity of the proposed model as a favorable alternative to computationally heavy Monte Carlo simulations. Moreover the model is suitable to study the sequence-dependent effects in the writhe transitions and offers good perspectives for further developments.
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收藏
页码：5704 / 5714
页数：11
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