Supercritical CO2 as a reaction medium for synthesis of capsaicin analogues by lipase-catalyzed transacylation of capsaicin

被引：6

作者：

Kobata, K ^{[1
]}

Kobayashi, M ^{[1
]}

Kinpara, S ^{[1
]}

Watanabe, T ^{[1
]}

机构：

[1] Univ Shizuoka, Sch Food & Nutr Sci, Shizuoka 4228526, Japan

来源：

BIOTECHNOLOGY LETTERS | 2003年 / 25卷 / 18期

关键词：

capsaicin analogues; lipase; supercritical carbon dioxide; transacylation;

D O I：

10.1023/A:1025428410952

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Capsaicin analogues having different acyl moiety were synthesized by lipase-catalyzed transacylation of capsaicin with a corresponding acyl donor in supercritical CO2 as a reaction medium. Transacylation with methyl tetradecanoate using Novozym 435 as a catalyst gave vanillyl tetradecanamide in a 54% yield at 80degreesC and 19 MPa over 72 h. Vanillyl (Z)-9-octadecenamide, olvanil, was synthesized from triolein in a 21% yield over 7 d.

引用

页码：1575 / 1578

页数：4

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