Patterns of recurrence in patients achieving pathologic complete response after neoadjuvant chemoradiotherapy for rectal cancer

被引：20
|
作者：
Fan, Wen-Hua [1 ,2 ]
Xiao, Jian [3 ]
An, Xin [1 ,4 ]
Jiang, Wu [1 ,2 ]
Li, Li-Ren [1 ,2 ]
Gao, Yuan-Hong [1 ,5 ]
Chen, Gong [1 ,2 ]
Kong, Ling-Heng [1 ,2 ]
Lin, Jun-Zhong [1 ,2 ]
Wang, Jian-Ping [6 ]
Pan, Zhi-Zhong [1 ,2 ]
Ding, Pei-Rong [1 ,2 ]
机构：
[1] Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Canc Ctr, Dept Colorectal Surg, Guangzhou, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Med Oncol, Guangzhou, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Canc Ctr, Dept Med Oncol, Guangzhou, Guangdong, Peoples R China
[5] Sun Yat Sen Univ, Canc Ctr, Dept Radiat Oncol, Guangzhou, Guangdong, Peoples R China
[6] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Colorectal Surg, Guangzhou, Guangdong, Peoples R China
来源：
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2017年 / 143卷 / 08期
关键词：
Rectal cancer; Neoadjuvant therapy; Chemoradiotherapy; Recurrence; TOTAL MESORECTAL EXCISION; PREOPERATIVE CHEMORADIOTHERAPY; LYMPH-NODES; PULMONARY METASTASES; CURATIVE RESECTION; POSTOPERATIVE CHEMORADIOTHERAPY; CLINICAL-SIGNIFICANCE; COLORECTAL-CANCER; SURGICAL SPECIMEN; CHEMORADIATION;
D O I：
10.1007/s00432-017-2383-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose Patients with locally advanced rectal cancer treated with neoadjuvant CRT and who achieved pCR from January 2004 to December 2012 were collected. The primary outcome measurement was the patterns of recurrence. Results Among 195 patients who achieved pCR, 18 developed recurrence. Furthermore, local recurrence occurred in 1.5% of patients (3/195), while distant metastases occurred in 7.7% of patients (15/195), which included 7 lung metastases, 1 liver metastasis, and 8 metastases in other locations. Conclusions Our study indicated that patients achieving pCR following neoadjuvant CRT have a favorable prognosis, with distant metastases predominating in all recurrences. Among patients with distant metastases, non-liver metastases were the predominant pattern.
引用
收藏
页码：1461 / 1467
页数：7
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