People with schizophrenia and depression have a low omega-3 index

被引：30
作者：
Parletta, Natalie [1 ]
Zarnowiecki, Dorota [1 ]
Cho, Jihyun [1 ]
Wilson, Amy [2 ]
Procter, Nicholas [3 ]
Gordon, Andrea [3 ]
Bogomolova, Svetlana [2 ]
O'Dea, Kerin [1 ]
Strachan, John [4 ]
Ballestrin, Matt [4 ]
Champion, Andrew [4 ]
Meyer, Barbara J. [5 ]
机构：
[1] Univ S Australia, Sch Hlth Sci, Sansom Inst Hlth Res, Ctr Populat Hlth Res, Adelaide, SA 5001, Australia
[2] Univ S Australia, Sch Business & Mkt, Adelaide, SA 5001, Australia
[3] Univ S Australia, Sch Nursing & Midwifery, Adelaide, SA 5001, Australia
[4] Local Southern Adelaide Hlth Network, Mental Hlth Directorate, Adelaide, SA, Australia
[5] Univ Wollongong, Sch Med, Wollongong, NSW, Australia
来源：
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2016年 / 110卷
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
Polyunsaturated fatty acids; Omega-3; index; Mental illness; Depression; Schizophrenia; Cardiovascular disease; RANDOMIZED CONTROLLED-TRIALS; C-REACTIVE PROTEIN; RISK-FACTOR; CONSTRUCT-VALIDITY; METABOLIC SYNDROME; NORMATIVE DATA; FATTY-ACIDS; FISH-OIL; OMEGA-3-FATTY-ACIDS; METAANALYSIS;
D O I：
10.1016/j.plefa.2016.05.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cardiovascular disease (CVD) is higher in people with mental illness and is associated with a 30 year higher mortality rate in this population. Erythrocyte docosahexaenoic acid (DHA) plus eicosapentaenoic acid (EPA) (omega-3 index) <= 4% is a marker for increased mortality risk from CVD while > 8% is protective. Omega-3 polyunsaturated fatty acids are also important for brain function and may ameliorate symptoms of mental illness. We investigated the erythrocyte omega-3 index in people with mental illness. One hundred and thirty adults aged 18-65 years (32.6% male) with schizophrenia (n=14) and depression (n=116) provided blood samples and completed physiological assessments and questionnaires. Both populations had risk factors for metabolic syndrome and CVD. The average omega-3 index was 3.95% (SD=1.06), compared to an estimated 5% in the Australian population. These data indicate an unfavourable omega-3 profile in people with mental illness that could contribute to higher CVD risk. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：42 / 47
页数：6
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