Statins in dermatology

被引：47

作者：

Jowkar, Farideh ^{[1
]}

Namazi, Mohammad Reza ^{[1
]}

机构：

[1] Shiraz Univ Med Sci, Dept Dermatol, Shiraz, Iran

来源：

INTERNATIONAL JOURNAL OF DERMATOLOGY | 2010年 / 49卷 / 11期

关键词：

COA REDUCTASE INHIBITOR; LICHENOID DRUG ERUPTION; SKIN BARRIER FUNCTION; NEUROFIBROMATOSIS TYPE-1; ANTIINFLAMMATORY ROLE; SYSTEMIC TREATMENT; GENE-EXPRESSION; MELANOMA-CELLS; RHO ACTIVITY; SIMVASTATIN;

D O I：

10.1111/j.1365-4632.2010.04579.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Statins are competitive inhibitors of 3-hydroxy-3-methylyglutaryl-coenzyme A reductase and reduce low-density lipoprotein-C levels. Statins are well-tolerated drugs used for prevention of atherosclerosis and cardiovascular events. Statins possess anti-inflammatory, immunomodulatory, antioxidant, metabolic, and possible anticancer effects. Statins are reported to be effective against psoriasis, dermatitis, graft-versus-host disease, uremic pruritus, vitiligo, and hirsutism. Topical forms of statins are employed in the treatment of acne, seborrhea, rosacea, and rhinophyma. Animal studies show the beneficial effect of statins against contact dermatitis and wound healing. They have promising anti-HIV effects as well. This article succinctly reviews the various cellular and molecular effects of statins, their applications in cutaneous medicine and their side effects.

引用

页码：1235 / 1243

页数：9

共 84 条

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