Prevention from hypoxia-induced apoptosis by pre-conditioning:: a mechanistic approach in cultured neurons from fetal rat forebrain

被引:29
作者
Bossenmeyer-Pourié, C [1 ]
Daval, JL [1 ]
机构
[1] Univ Henri Poincare, JE Adaptat Neonatale & Dev 2164, F-54013 Nancy, France
来源
MOLECULAR BRAIN RESEARCH | 1998年 / 58卷 / 1-2期
关键词
developing brain neuron; hypoxia; pre-conditioning; apoptosis; mitosis; Bcl-2; PCNA;
D O I
10.1016/S0169-328X(98)00123-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Molecular effects of pre-conditioning by 1-h hypoxia were investigated in cultured neurons from fetal rat forebrain, submitted the following day to a 6-h hypoxia that induces apoptosis. While preventing from apoptosis, pre-conditioning led to increased number of living neurons, DNA synthesis, with persistent overexpression of Bcl-2 and proliferating cell nuclear antigen (PCNA). Adaptative mechanisms would involve anti-apoptotic proteins and regulators of the cell cycle, to finally promote neuronal proliferation. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:237 / 239
页数:3
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