Defining Stage III Disease in Colorectal Cancer-Aspects on Treatment and Evaluation of Survival

被引:6
作者
Derwinger, Kristoffer [1 ]
Carlsson, Goran [1 ]
Ekman, Tor [2 ]
机构
[1] Sahlgrens Univ Hosp, Dept Surg, S-41685 Gothenburg, Sweden
[2] Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden
关键词
colorectal cancer; cancer staging; adjuvant chemotherapy; palliative chemotherapy; lymph node ratio; survival; prognosis; COLON-CANCER; ADJUVANT THERAPY; RATIO;
D O I
10.1002/jso.21567
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background and Objective: Stage III in colorectal cancer is defined by presence of node metastasis, whereas distant growth constitutes stage IV The aim was to describe prognosis in high risk groups of stage III in relation to survival in stage IV, along with possible effect on research and treatment Methods: All patients operated for stage III-IV colorectal cancer 1999-2003 n = 591) were assessed by demography. pathology and treatment towards survival Stage III patients were grouped by lymph node ratio (LNR) tenths and stage IV by node status (N0-2) Comparison was by cancer specific survival (CSS) Disease free survival (DFS) was also assessed for stage III Results: LNR predicted CSS and DFS (P < 0 001) as a higher ratio correlated with a worse prognosis and an increased risk of early recurrence With high ratios the stage III survival prognosis resembled stage IV A survival crossover phenomenon was found for stage III patients with a high LNR (0 9-1.) compared to some stage IV patients (N0/MI) Conclusions: The prognosis in stage III is heterogeneous and can be differentiated by LNR The survival difference towards stage IV can be limited which could affect the use and evaluation of chemotherapy and the further development of staging terminology J Surg Oncol 2010,102 424-427 (C) 2010 Wiley-Liss. Inc
引用
收藏
页码:424 / 427
页数:4
相关论文
共 50 条
  • [31] Tumor aggression-defense index-a novel indicator to predicts recurrence and survival in stage II-III colorectal cancer
    Wu, Tong
    Fang, Lin
    Ruan, Yuli
    Shi, Mengde
    Su, Dan
    Ma, Yue
    Ma, Ming
    Wang, Bojun
    Liao, Yuanyu
    Han, Shuling
    Lu, Xiaolin
    Zhang, Chunhui
    Liu, Chao
    Zhang, Yanqiao
    [J]. JOURNAL OF TRANSLATIONAL MEDICINE, 2025, 23 (01)
  • [32] Deep learning with whole slide images can improve the prognostic risk stratification with stage III colorectal cancer
    Sun, Caixia
    Li, Bingbing
    Wei, Genxia
    Qiu, Weihao
    Li, Danyi
    Li, Xiangzhao
    Liu, Xiangyu
    Wei, Wei
    Wang, Shuo
    Liu, Zhenyu
    Tian, Jie
    Liang, Li
    [J]. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, 2022, 221
  • [33] Evaluation of LNR and modified N stage systems for prognostic stratification of metastatic lymph nodes in stage III colorectal Cancer
    Zhao-Fu Qin
    Xin-Yi Gao
    Yan-Zhi Zhu
    Ting Ma
    Guan-Liang Chen
    De-Ning Ma
    Hong-Zhou Zhu
    Long-Hai Feng
    [J]. Scientific Reports, 15 (1)
  • [34] Lymph Node Evaluation and Survival in Colorectal Cancer: Review of Population-based, Prospective Studies
    Akagi, Yoshito
    Adachi, Yosuke
    Kinugasa, Tetsushi
    Oka, Yosuke
    Mizobe, Tomoaki
    Shirouzu, Kazuo
    [J]. ANTICANCER RESEARCH, 2013, 33 (07) : 2839 - 2847
  • [35] Rectal Cancer Patients Younger Than 50 Years Lack a Survival Benefit From NCCN Guideline-Directed Treatment for Stage II and III Disease
    Kolarich, Andrew
    George, Thomas J., Jr.
    Hughes, Steven J.
    Delitto, Daniel
    Allegra, Carmen J.
    Hall, William A.
    Chang, George J.
    Tan, Sanda A.
    Shaw, Christiana M.
    Iqbal, Atif
    [J]. CANCER, 2018, 124 (17) : 3510 - 3519
  • [36] Treatment patterns and primary reasons for adjusted treatment in older and younger patients with stage II or III colorectal cancer
    Scheepers, E. R. M.
    Schiphorst, A. H.
    Van Huis-Tanja, L. H.
    Emmelot-Vonk, M. H.
    Hamaker, M. E.
    [J]. EJSO, 2021, 47 (07): : 1675 - 1682
  • [37] Postoperative serum interleukin-6 levels correlate with survival in stage I-III colorectal cancer
    Feng, Shouhan
    Li, Zeshi
    Liu, Mei
    Ye, Qianwen
    Xue, Tianhui
    Yan, Bing
    [J]. BMC GASTROENTEROLOGY, 2023, 23 (01)
  • [38] The Impact of Muscle and Adipose Tissue on Long-term Survival in Patients With Stage I to III Colorectal Cancer
    Hopkins, Jessica J.
    Reif, Rebecca L.
    Bigam, David L.
    Baracos, Vickie E.
    Eurich, Dean T.
    Sawyer, Michael B.
    [J]. DISEASES OF THE COLON & RECTUM, 2019, 62 (05) : 549 - 560
  • [39] Impact of Postoperative Naples Prognostic Score to Predict Survival in Patients with Stage II-III Colorectal Cancer
    Park, Su Hyeong
    Woo, Hye Seung
    Hong, In Kyung
    Park, Eun Jung
    [J]. CANCERS, 2023, 15 (20)
  • [40] Lymph Node Evaluation and Long-Term Survival in Stage II and Stage III Colon Cancer: A National Study
    Vather, Ryash
    Sammour, Tarik
    Kahokehr, Arman
    Connolly, Andrew B.
    Hill, Andrew G.
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2009, 16 (03) : 585 - 593