Defining Stage III Disease in Colorectal Cancer-Aspects on Treatment and Evaluation of Survival

被引:6
作者
Derwinger, Kristoffer [1 ]
Carlsson, Goran [1 ]
Ekman, Tor [2 ]
机构
[1] Sahlgrens Univ Hosp, Dept Surg, S-41685 Gothenburg, Sweden
[2] Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden
关键词
colorectal cancer; cancer staging; adjuvant chemotherapy; palliative chemotherapy; lymph node ratio; survival; prognosis; COLON-CANCER; ADJUVANT THERAPY; RATIO;
D O I
10.1002/jso.21567
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background and Objective: Stage III in colorectal cancer is defined by presence of node metastasis, whereas distant growth constitutes stage IV The aim was to describe prognosis in high risk groups of stage III in relation to survival in stage IV, along with possible effect on research and treatment Methods: All patients operated for stage III-IV colorectal cancer 1999-2003 n = 591) were assessed by demography. pathology and treatment towards survival Stage III patients were grouped by lymph node ratio (LNR) tenths and stage IV by node status (N0-2) Comparison was by cancer specific survival (CSS) Disease free survival (DFS) was also assessed for stage III Results: LNR predicted CSS and DFS (P < 0 001) as a higher ratio correlated with a worse prognosis and an increased risk of early recurrence With high ratios the stage III survival prognosis resembled stage IV A survival crossover phenomenon was found for stage III patients with a high LNR (0 9-1.) compared to some stage IV patients (N0/MI) Conclusions: The prognosis in stage III is heterogeneous and can be differentiated by LNR The survival difference towards stage IV can be limited which could affect the use and evaluation of chemotherapy and the further development of staging terminology J Surg Oncol 2010,102 424-427 (C) 2010 Wiley-Liss. Inc
引用
收藏
页码:424 / 427
页数:4
相关论文
共 50 条
[21]   Association Between Inflammatory Bowel Disease and Colorectal Cancer Stage of Disease and Survival [J].
Taylor, Christopher C. ;
Millien, Valentine O. ;
Hou, Jason K. ;
Massarweh, Nader N. .
JOURNAL OF SURGICAL RESEARCH, 2020, 247 :77-85
[22]   Increased Lymph Node Evaluation With Colorectal Cancer Resection Does It Improve Detection of Stage III Disease? [J].
Kukreja, Sachin S. ;
Esteban-Agusti, Enrique ;
Velasco, Jose M. ;
Hieken, Tina J. .
ARCHIVES OF SURGERY, 2009, 144 (07) :612-616
[23]   An evaluation and replication of miRNAs with disease stage and colorectal cancer-specific mortality [J].
Slattery, Martha L. ;
Herrick, Jennifer S. ;
Mullany, Lila E. ;
Valeri, Nicola ;
Stevens, John ;
Caan, Bette J. ;
Samowitz, Wade ;
Wolff, Roger K. .
INTERNATIONAL JOURNAL OF CANCER, 2015, 137 (02) :428-438
[24]   Microsatellite instability is associated with reduced disease specific survival in stage III colon cancer [J].
Mohan, H. M. ;
Ryan, E. ;
Balasubramanian, I. ;
Kennelly, R. ;
Geraghty, R. ;
Sclafani, F. ;
Fennelly, D. ;
McDermott, R. ;
Ryan, E. J. ;
O'Donoghue, D. ;
Hyland, J. M. P. ;
Martin, S. T. ;
O'Connell, P. R. ;
Gibbons, D. ;
Des Winter ;
Sheahan, K. .
EJSO, 2016, 42 (11) :1680-1686
[25]   Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancer [J].
Shanmugam, Chandrakumar ;
Hines, Robert B. ;
Jhala, Nirag C. ;
Katkoori, Venkat R. ;
Zhang, Bin ;
Posey, James A., Jr. ;
Bumpers, Harvey L. ;
Grizzle, William E. ;
Eltoum, Isam E. ;
Siegal, Gene P. ;
Manne, Upender .
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2011, 4
[26]   Extranodal extension status is a powerful prognostic factor in stage III colorectal cancer [J].
Kim, Chan Wook ;
Kim, Jihun ;
Yeom, Seung-Seop ;
Lee, Jong Lyul ;
Yoon, Yong Sik ;
Park, In Ja ;
Lim, Seok-Byung ;
Baek, Seunghee ;
Yu, Chang Sik ;
Kim, Jin Cheon .
ONCOTARGET, 2017, 8 (37) :61393-61403
[27]   Prognostic impact of lymph node skip metastasis in Stage III colorectal cancer [J].
Bao, F. ;
Zhao, L. -Y. ;
Balde, A. I. ;
Liu, H. ;
Yan, J. ;
Li, T. -T. ;
Chen, H. ;
Li, G. -X. .
COLORECTAL DISEASE, 2016, 18 (09) :O322-O329
[28]   Tumor-associated macrophages and risk of recurrence in stage III colorectal cancer [J].
Cavalleri, Tommaso ;
Greco, Luana ;
Rubbino, Federica ;
Hamada, Tsuyoshi ;
Quaranta, Maria ;
Grizzi, Fabio ;
Sauta, Elisabetta ;
Craviotto, Vincenzo ;
Bossi, Paola ;
Vetrano, Stefania ;
Rimassa, Lorenza ;
Torri, Valter ;
Bellazzi, Riccardo ;
Mantovani, Alberto ;
Ogino, Shuji ;
Malesci, Alberto ;
Laghi, Luigi .
JOURNAL OF PATHOLOGY CLINICAL RESEARCH, 2022, 8 (04) :307-312
[29]   A Lymph Node Ratio of 10% Is Predictive of Survival in Stage III Colon Cancer: A French Regional Study [J].
Sabbagh, Charles ;
Mauvais, Francois ;
Cosse, Cyril ;
Rebibo, Lionel ;
Joly, Jean-Paul ;
Dromer, Didier ;
Aubert, Christine ;
Carton, Sophie ;
Dron, Bernard ;
Dadamessi, Innocenti ;
Maes, Bernard ;
Perrier, Guillaume ;
Manaouil, David ;
Fontaine, Jean-Fran Cois ;
Gozy, Michel ;
Panis, Xavier ;
Foncelle, Pierre Henri ;
de Fresnoy, Hugues ;
Leroux, Fabien ;
Vaneslander, Pierre ;
Ghighi, Caroline ;
Regimbeau, Jean-Marc .
INTERNATIONAL SURGERY, 2014, 99 (04) :344-353
[30]   Neuroendocrine differentiation is predictive of poor survival in patients with stage II colorectal cancer [J].
Liu, Yue ;
He, Jinjie ;
Xu, Jinghong ;
Li, Jun ;
Jiao, Yurong ;
Bei, Dikai ;
Hu, Yeting ;
Chen, Haiyan ;
Xiao, Qian ;
Ding, Kefeng .
ONCOLOGY LETTERS, 2017, 13 (04) :2230-2236