Surface modification of biodegradable porous Mg bone scaffold using polycaprolactone/bioactive glass composite

被引:90
作者
Yazdimamaghani, Mostafa [1 ]
Razavi, Mehdi [1 ]
Vashaee, Daryoosh [2 ]
Tayebi, Lobat [1 ,3 ]
机构
[1] Oklahoma State Univ, Helmerich Adv Technol Res Ctr, Sch Mat Sci & Engn, Tulsa, OK 74106 USA
[2] N Carolina State Univ, Elect & Comp Engn Dept, Raleigh, NC 27606 USA
[3] Marquette Univ, Sch Dent, Dept Dev Sci, Milwaukee, WI 53201 USA
来源
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2015年 / 49卷
基金
美国国家科学基金会;
关键词
Magnesium; Scaffold; Coating; Biomaterials; MAGNESIUM ALLOY; IN-VITRO; BIOACTIVE GLASS; DEGRADATION BEHAVIOR; STAINLESS-STEEL; TISSUE; IMPLANTS; COATINGS;
D O I
10.1016/j.msec.2015.01.041
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
A reduction in the degradation rate of magnesium (Mg) and its alloys is in high demand to enable these materials to be used in orthopedic applications. For this purpose, in this paper, a biocompatible polymeric layer reinforced with a bioactive ceramic made of polycaprolactone (PCL) and bioactive glass (BG) was applied on the surface of Mg scaffolds using dip-coating technique under low vacuum. The results indicated that the PCL-BG coated Mg scaffolds exhibited noticeably enhanced bioactivity compared to the uncoated scaffold. Moreover, the mechanical integrity of the Mg scaffolds was improved using the Pa-BG coating on the surface. The stable barrier property of the coatings effectively delayed the degradation activity of Mg scaffold substrates. Moreover, the coatings induced the formation of apatite layer on their surface after immersion in the SBF, which can enhance the biological bone in-growth and block the microcracks and pore channels in the coatings, thus prolonging their protective effect. Furthermore, it was shown that a three times increase in the concentration of PCL-BG noticeably improved the characteristics of scaffolds including their degradation resistance and mechanical stability. Since bioactivity, degradation resistance and mechanical integrity of a bone substitute are the key factors for repairing and healing fractured bones, we suggest that PCL-BG is a suitable coating material for surface modification of Mg scaffolds. Published by Elsevier B.V.
引用
收藏
页码:436 / 444
页数:9
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