Nonparametric 5D D-R2 distribution imaging with single-shot EPI at 21.1 T: Initial results for in vivo rat brain

被引:2
作者
Rosenberg, Jens T. [1 ]
Grant, Samuel C. [1 ,2 ]
Topgaard, Daniel [3 ]
机构
[1] Florida State Univ, Natl High Magnet Field Lab, Tallahassee, FL 32306 USA
[2] Florida State Univ, FAMU FSU Coll Engn, Chem & Biomed Engn, Tallahassee, FL 32306 USA
[3] Lund Univ, Phys Chem, Lund, Sweden
基金
美国国家科学基金会; 瑞典研究理事会; 美国国家卫生研究院;
关键词
Multidimensional diffusion encoding; Diffusion-relaxation correlation; Ultra-high field; 21.1; T; In vivo; MICROSCOPIC DIFFUSION ANISOTROPY; MAGNETIC-RESONANCE; MRI; RELAXATION; NMR; MICROSTRUCTURE; HETEROGENEITY; ECCENTRICITY; SPECTROSCOPY; VALIDATION;
D O I
10.1016/j.jmr.2022.107256
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
In vivo human diffusion MRI is by default performed using single-shot EPI with greater than 50-ms echo times and associated signal loss from transverse relaxation. The individual benefits of the current trends of increasing B-0 to boost SNR and employing more advanced signal preparation schemes to improve the specificity for selected microstructural properties eventually may be cancelled by increased relaxation rates at high B-0 and echo times with advanced encoding. Here, initial attempts to translate state-ofthe-art diffusion-relaxation correlation methods from 3 T to 21.1 T are made to identify hurdles that need to be overcome to fulfill the promises of both high SNR and readily interpretable microstructural information. (C) 2022 Elsevier Inc. All rights reserved.
引用
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页数:9
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