The protease inhibitor bikunin, a novel anti-metastatic agent

被引：66

作者：

Kobayashi, H ^{[1
]}

Suzuki, M ^{[1
]}

Hirashima, Y ^{[1
]}

Terao, T ^{[1
]}

机构：

[1] Hamamatsu Univ Sch Med, Dept Obstet & Gynecol, Shizuoka 4313192, Japan

来源：

BIOLOGICAL CHEMISTRY | 2003年 / 384卷 / 05期

关键词：

bikunin; CD44; Kunitz-type protease inhibitor; metastasis; urokinase-type plasminogen activator;

D O I：

10.1515/BC.2003.083

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bikunin is a Kunitz-type protease inhibitor predominantly found in human amniotic fluid. In cancers, administration of bikunin may block tumor cell invasion by a direct inhibition of tumor cell-associated plasmin activity as well as by inhibiting urokinase-type plasminogen activator (uPA) expression at the gene and protein levels, possibly through suppression of CD44 dimerization and/or the MAP kinase signaling cascade. Treatment of cancer patients with bikunin may be beneficial in the adjuvant setting to delay the onset of metastasis development and/or, in combination with cytotoxic agents to improve treatment efficacy in patients with advanced ovarian cancer.

引用

页码：749 / 754

页数：6

共 44 条

[1] Characterization of placental bikunin, a novel human serine protease inhibitor [J].

Delaria, KA ;

Muller, DK ;

Marlor, CW ;

Brown, JE ;

Das, RC ;

Roczniak, SO ;

Tamburini, PP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (18) :12209-12214

[2] Cancer treatment with inhibitors of urokinase-type plasminogen activator and plasmin [J].

Dunbar, SD ;

Ornstein, DL ;

Zacharski, LR .

EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2000, 9 (09) :2085-2092

[3] Effects of urinary trypsin inhibitor on myometrial contraction in term and preterm deliveries [J].

ElMaradny, E ;

Kanayama, N ;

Halim, A ;

Maehara, K ;

Kobayashi, T ;

Terao, T .

GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 1996, 41 (02) :96-102

[4] A peptide derived from the nonreceptor binding region of urokinase plasminogen activator (uPA) inhibits tumor progression and angiogenesis and induces tumor cell death in vivo [J].

Guo, YJ ;

Higazi, AA ;

Arakelian, A ;

Sachais, BS ;

Cines, D ;

Goldfarb, RH ;

Jones, TR ;

Kwaan, H ;

Mazar, AP ;

Rabbani, SA .

FASEB JOURNAL, 2000, 14 (10) :1400-1410

[5] Adhesion proteins in the biology of breast cancer: Contribution of CD44 [J].

Herrera-Gayol, A ;

Jothy, S .

EXPERIMENTAL AND MOLECULAR PATHOLOGY, 1999, 66 (02) :149-156

[6] Characterization of binding properties of urinary trypsin inhibitor to cell-associated binding sites on human chondrosarcoma cell line HCS-2/8 [J].

Hirashima, Y ;

Kobayashi, H ;

Suzuki, M ;

Tanaka, Y ;

Kanayama, N ;

Fujie, M ;

Nishida, T ;

Takigawa, M ;

Terao, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (17) :13650-13656

[7] Urinary trypsin inhibitor suppresses vascular smooth muscle contraction by inhibition of Ca2+ influx [J].

Kanayama, N ;

Maehara, K ;

She, LP ;

Belayet, HM ;

Khatun, S ;

Tokunaga, N ;

Terao, T .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1998, 1381 (02) :139-146

[8] KUNITZ-TYPE TRYPSIN-INHIBITOR PREVENTS LPS-INDUCED INCREASE OF CYTOSOLIC-FREE CA2+ IN HUMAN NEUTROPHILS AND HUVEC CELLS [J].

KANAYAMA, N ;

HALIM, A ;

MAEHARA, K ;

KAJIWARA, Y ;

FUJIE, M ;

TERAO, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 207 (01) :324-330

[9] URINARY TRYPSIN-INHIBITOR PREVENTS UTERINE MUSCLE-CONTRACTION BY INHIBITION OF CA++ INFLUX [J].

KANAYAMA, N ;

ELMARADNY, E ;

HALIM, A ;

SHE, LP ;

MAEHARA, K ;

KAJIWARA, Y ;

TERAO, T .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1995, 173 (01) :192-199

[10] The role of chondroitin sulfate chains of urinary trypsin inhibitor in inhibition of LPS-induced increase of cytosolic free Ca2+ in HL60 cells and HUVEC cells [J].

Kanayama, N ;

Maehara, K ;

Suzuki, M ;

Fujise, Y ;

Terao, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 238 (02) :560-564

← 1 2 3 4 5 →