Contribution of platelets to tumour metastasis

被引：1283

作者：

Gay, Laurie J. ^{[1
]}

Felding-Habermann, Brunhilde ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

来源：

NATURE REVIEWS CANCER | 2011年 / 11卷 / 02期

基金：

美国国家卫生研究院;

关键词：

ENDOTHELIAL GROWTH-FACTOR; TISSUE FACTOR ACTIVITY; VON-WILLEBRAND-FACTOR; BREAST-CANCER; P-SELECTIN; COAGULATION ACTIVATION; INTEGRIN ACTIVATION; LUNG METASTASIS; PROCOAGULANT FUNCTION; CARCINOMA MUCINS;

D O I：

10.1038/nrc3004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.

引用

页码：123 / 134

页数：12

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