Circulating CD4+PD-1+and CD8+PD-1+T cells are profoundly decreased at the onset of fulminant type 1 diabetes and are restored by treatment, contrasting with CD4+CD25+FoxP3+regulatory T cells

被引：16

作者：

Iijima, Toshie ^{[1
]}

Kato, Kanako ^{[1
]}

Jojima, Teruo ^{[1
]}

Tomotsune, Takanori ^{[1
]}

Fukushima, Maiko ^{[2
]}

Suzuki, Kunihiro ^{[1
]}

Aso, Yoshimasa ^{[1
]}

机构：

[1] Dokkyo Med Univ, Dept Endocrinol & Metab, Shimotsuga, Tochigi 3210293, Japan

[2] LSI Medience, Tokyo, Japan

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2017年 / 133卷

关键词：

ANTI-PD-1; PD-1; MICE;

D O I：

10.1016/j.diabres.2017.07.036

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Programed cell death protein-1 (PD-1) is an inhibitory receptor expressed by T cells that downregulates the activation and proliferation of these cells to maintain peripheral self-tolerance. Recent studies reported some cases of new-onset type 1 diabetes (T1D) under anti-PD1 or PDL-1 antibodies. We demonstrated that circulating both CD4+PD-1+ and CD8+PD-1+ T cells were profoundly reduced at the onset of fulminant T1D and were restored by treatment in two patients with fulminant T1D. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：10 / 12

页数：3

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