Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells

被引：935

作者：

Frankel, Lisa B. ^{[1
]}

Christoffersen, Nanna R. ^{[1
]}

Jacobsen, Anders ^{[1
,2
]}

Lindow, Morten ^{[1
,2
]}

Krogh, Anders ^{[1
,2
]}

Lund, Anders H. ^{[1
,3
]}

机构：

[1] Univ Copenhagen, Biotech Res & Innovat Ctr, DK-2200 Copenhagen, Denmark

[2] Univ Copenhagen, Bioinformat Ctr, DK-2200 Copenhagen, Denmark

[3] Univ Copenhagen, Ctr Epigenet, DK-2200 Copenhagen, Denmark

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2008年 / 283卷 / 02期

关键词：

D O I：

10.1074/jbc.M707224200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs are emerging as important regulators of cancer-related processes. The miR-21 microRNA is overexpressed in a wide variety of cancers and has been causally linked to cellular proliferation, apoptosis, and migration. Inhibition of mir-21 in MCF-7 breast cancer cells causes reduced cell growth. Using array expression analysis of MCF-7 cells depleted of miR-21, we have identified mRNA targets of mir-21 and have shown a link between miR-21 and the p53 tumor suppressor protein. We furthermore found that the tumor suppressor protein Programmed Cell Death 4 (PDCD4) is regulated by miR-21 and demonstrated that PDCD4 is a functionally important target for miR-21 in breast cancer cells.

引用

页码：1026 / 1033

页数：8

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