Emerging Trends in Heart Valve Engineering: Part I. Solutions for Future

被引：64

作者：

Kheradvar, Arash ^{[1
,2
]}

Groves, Elliott M. ^{[1
,2
]}

Dasi, Lakshmi P. ^{[3
]}

Alavi, S. Hamed ^{[1
]}

Tranquillo, Robert ^{[4
]}

Grande-Allen, K. Jane ^{[5
]}

Simmons, Craig A. ^{[6
,7
]}

Griffith, Boyce ^{[8
,9
]}

Falahatpisheh, Ahmad ^{[1
]}

Goergen, Craig J. ^{[10
]}

Mofrad, Mohammad R. K. ^{[11
]}

Baaijens, Frank ^{[12
]}

Little, Stephen H. ^{[13
]}

Canic, Suncica ^{[14
]}

机构：

[1] Univ Calif Irvine, Dept Biomed Engn, Edwards Lifesci Ctr Adv Cardiovasc Technol, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Irvine Sch Med, Dept Internal Med, Div Cardiol, Irvine, CA 92697 USA

[3] Colorado State Univ, Dept Mech Engn, Sch Biomed Engn, Ft Collins, CO 80523 USA

[4] Univ Minnesota, Dept Biomed Engn, Minneapolis, MN USA

[5] Rice Univ, Dept Bioengn, Houston, TX USA

[6] Univ Toronto, Dept Mech & Ind Engn, Toronto, ON, Canada

[7] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON, Canada

[8] Univ N Carolina, Dept Math, Ctr Interdisciplinary Appl Math, Chapel Hill, NC USA

[9] Univ N Carolina, Sch Med, McAllister Heart Inst, Chapel Hill, NC USA

[10] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA

[11] Univ Calif Berkeley, Dept Bioengn & Mech Engn, Berkeley, CA 94720 USA

[12] Eindhoven Univ Technol, Dept Biomed Engn, NL-5600 MB Eindhoven, Netherlands

[13] Houston Methodist DeBakey Heart & Vasc Ctr, Houston, TX USA

[14] Univ Houston, Dept Math, Houston, TX 77204 USA

来源：

ANNALS OF BIOMEDICAL ENGINEERING | 2015年 / 43卷 / 04期

基金：

美国国家科学基金会;

关键词：

Heart valve engineering; Tissue engineered heart valves; Polymeric heart valves; VALVULAR INTERSTITIAL-CELLS; AORTIC-VALVE; EXTRACELLULAR-MATRIX; SPECIAL DESIGN; IN-VITRO; NANOCOMPOSITE POLYMER; MECHANICAL EVALUATION; HYDRODYNAMIC FUNCTION; LEAFLET REPLACEMENT; PROSTHESIS DESIGN;

D O I：

10.1007/s10439-014-1209-z

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

As the first section of a multi-part review series, this section provides an overview of the ongoing research and development aimed at fabricating novel heart valve replacements beyond what is currently available for patients. Here we discuss heart valve replacement options that involve a biological component or process for creation, either in vitro or in vivo (tissue-engineered heart valves), and heart valves that are fabricated from polymeric material that are considered permanent inert materials that may suffice for adults where growth is not required. Polymeric materials provide opportunities for cost-effective heart valves that can be more easily manufactured and can be easily integrated with artificial heart and ventricular assist device technologies. Tissue engineered heart valves show promise as a regenerative patient specific model that could be the future of all valve replacement. Because tissue-engineered heart valves depend on cells for their creation, understanding how cells sense and respond to chemical and physical stimuli in their microenvironment is critical and therefore, is also reviewed.

引用

页码：833 / 843

页数：11

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