Serious consequences of Epstein-Barr virus infection: Hemophagocytic lymphohistocytosis

被引：7
作者：
Xu, Lingyue [1 ]
Guo, Xiaofang [1 ]
Guan, Hongzai [1 ]
机构：
[1] Qingdao Univ, Dept Clin Hematol, Sch Med, Ningde Rd 16, Qingdao 266071, Peoples R China
来源：
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY | 2022年 / 44卷 / 01期
关键词：
Epstein-Barr virus; hemophagocytic lymphohistocytosis; hemophagocytic syndrome; STEM-CELL TRANSPLANTATION; LYMPHOPROLIFERATIVE DISEASES; HOST-DISEASE; LYMPHOHISTIOCYTOSIS; EBV; IDENTIFICATION; ETOPOSIDE; BLOCKADE; PROTEIN; SH2D1A;
D O I：
10.1111/ijlh.13736
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Human is the host of the Epstein-Barr virus (EBV) especially in childhood and adolescence. Most of them are asymptomatic infection and self-limiting. However, for those patients who suffer from immune dysfunction, EBV infection will be life-threatening. Epstein-Barr virus-associated hemophagocytic lymphohistocytosis (EBV-HLH) is one of the severe effects. The diagnosis and differential diagnosis of EBV-HLH and other EBV infectious diseases are mentioned in this paper. The molecular biology mechanism and complications of EBV-HLH are equally briefly presented. It also provides a practical method for the genetic diagnosis of such diseases and the differential diagnosis with other human immunodeficiency diseases for medical scientists in routine clinical practice.
引用
收藏
页码：74 / 81
页数：8
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