Argonaute proteins: key players in RNA silencing

被引：968

作者：

Hutvagner, Gyorgy ^{[1
]}

Simard, Martin J. ^{[2
]}

机构：

[1] Univ Dundee, Wellcome Trust Ctr Gene Regulat & Express, Coll Life Sci, Dundee DD1 5EH, Scotland

[2] Univ Laval, Canc Res Ctr, Hotel Dieu, Quebec City, PQ G1R 2J6, Canada

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nrm2321

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During the past decade, small non-coding RNAs have rapidly emerged as important contributors to gene regulation. To carry out their biological functions, these small RNAs require a unique class of proteins called Argonautes. The discovery and our comprehension of this highly conserved protein family is closely linked to the study of RNAbased gene silencing mechanisms. With their functional domains, Argonaute proteins can bind small non-coding RNAs and control protein synthesis, affect messenger RNA stability and even participate in the production of a new class of small RNAs, Piwi-interacting RNAs.

引用

页码：22 / 32

页数：11

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